Measuring and modeling of melt viscosity for drug polymer mixtures

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dc.contributor.authorKimmel, Vincent
dc.contributor.authorErcolin, Enrico
dc.contributor.authorZimmer, Robin
dc.contributor.authorYörük, Muhammet
dc.contributor.authorWinck, Judith
dc.contributor.authorThommes, Markus
dc.date.accessioned2024-02-23T12:34:46Z
dc.date.available2024-02-23T12:34:46Z
dc.date.issued2024-02-21
dc.description.abstractMelt viscosity is an essential property in pharmaceutical processes such as mixing, extrusion, fused deposition modeling, and melt coating. Measuring and modeling of the melt viscosity for drug/polymer mixtures is essential for optimization of the manufacturing process. In this work, the melt viscosity of nine formulations containing the drug substances acetaminophen, itraconazole, and griseofulvin, as well as the pharmaceutical polymers Eudragit EPO, Soluplus, and Plasdone S-630, were analyzed with a rotational and oscillatory rheometer. The shear rate, temperature, and drug fraction were varied systematically to investigate their influence on viscosity. The results for the pure polymers showed typical shear-thinning behavior and are fundamental for modeling with the Carreau and Arrhenius approaches. The investigations of the viscosity of the drug/polymer mixtures resulted in a plasticizing or a filler effect, depending on the type of drug and the phase behavior. A drug shift factor was proposed to model the change in viscosity as a function of the drug fraction. On this basis, a universal model to describe the melt viscosity of drug/polymer mixtures was developed, considering shear rate, temperature, and drug fraction.en
dc.identifier.urihttp://hdl.handle.net/2003/42352
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-24189
dc.language.isoende
dc.relation.ispartofseriesPharmaceutics;16(3)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/de
dc.subjectAmorphous solid dispersionsen
dc.subjectRheologyen
dc.subjectViscosityen
dc.subjectPlasticizingen
dc.subjectFilleren
dc.subjectDrugen
dc.subjectPolymersen
dc.subjectModelingen
dc.subject.ddc660
dc.subject.rswkFeststoffde
dc.subject.rswkDispersionde
dc.subject.rswkRheologiede
dc.subject.rswkViskositätde
dc.subject.rswkPlastifizierende
dc.subject.rswkFüllstoffde
dc.subject.rswkArzneimittelde
dc.subject.rswkPolymerede
dc.subject.rswkModellierungde
dc.titleMeasuring and modeling of melt viscosity for drug polymer mixturesen
dc.typeTextde
dc.type.publicationtypeArticlede
dcterms.accessRightsopen access
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationKimmel, V.; Ercolin, E.; Zimmer, R.; Yörük, M.; Winck, J.; Thommes, M. Measuring and Modeling of Melt Viscosity for Drug Polymer Mixtures. Pharmaceutics 2024, 16, 301. https://doi.org/10.3390/pharmaceutics16030301de
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.3390/pharmaceutics16030301de

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