This thesis focuses on the impact of financial markets on innovation. On the one hand, this includes the analysis of the sensitivity of innovative firms to restrictions in external financing. On the other hand, the reaction of innovation activities to changes in the supply of external financing is investigated. In that respect, in particular the lack of access to and supply of bank financing in the recent financial crisis is being used as source of underinvestment in innovation. The second ch...

Urban residents’ need to be in control of their home environment can be constrained by perceived uncontrollability of exposure to road traffic noise. Noise annoyance may indicate a psychological stress reaction due to this uncontrollability perception, thereby undermining the restoration process. Environmental resources, such as having access to a quiet side at home and dwelling-related green, may reduce noise annoyance both directly by shielding acoustically and indirectly by enhancing resid...

Extensive phytochemical analysis of different root fractions of Jatropha pelargoniifolia Courb. (Euphorbiaceae) has resulted in the isolation and identification of 22 secondary metabolites. 6-hydroxy-8-methoxycoumarin-7-O-β-d-glycopyranoside (15) and 2-hydroxymethyl N-methyltryptamine (18) were isolated and identified as new compounds along with the known diterpenoid (1, 3, 4, and 7), triterpenoid (2 and 6), flavonoid (5, 11, 13, 14, and 16), coumarinolignan (8–10), coumarin (15), pyrimidine ...

Fusicocca-2,10(14)-diene (FCdiene) is a tricyclic diterpene which has many pharmaceutical applications, for example, it is a precursor for different anticancer drugs, including fusicoccin A. Chemical synthesis of this diterpene is not economical as it requires 14 steps with several stereospecific reactions. FCdiene is naturally produced at low titers in phytopathogenic filamentous fungi. However, production of FCdiene can be achieved via expression of fusicoccadiene synthase in yeast. The obj...

For the design of the next generation of microelectronic packages, thermal management is one of the key aspects and must be met by the development of polymers with enhanced thermal conductivity. While all polymer classes show a very low thermal conductivity, this shortcoming can be compensated for by the addition of fillers, yielding polymer-based composite materials with high thermal conductivity. The inorganic fillers, however, are often available only in submicron- and micron-scaled dimens...

Rapid urbanization has dramatically spurred economic development since the 1980s, especially in China, but has had negative impacts on natural resources since it is an irreversible process. Thus, timely monitoring and quantitative analysis of the changes in land use over time and identification of landscape pattern variation related to growth modes in different periods are essential. This study aimed to inspect spatiotemporal characteristics of landscape pattern responses to land use changes ...

Das kumulative Promotionsvorhaben beschäftigt sich in international vergleichender Perspektive mit der Qualifizierung von Dienstleistungsstandorten der urbanen Peripherie. Dazu werden drei Beispielregionen aus Deutschland (Frankfurt am Main), der Schweiz (Zürich) und den USA (Boston) betrachtet und abschließend zusammenfassend dargestellt. Im Zuge zunehmender Regionalisierungstendenzen großer Metropolregionen zu polycentric urban regions (Kloosterman & Musterd 2001; Meijers 2005) oder megacit...

Für die trennende Bearbeitung von Beton und Stahlbeton werden in großem Umfang diamantimprägnierte Schleifwerkzeuge eingesetzt. Die spezifische Herausforderung stellt dabei das Verbundverhalten aus sprödhartem Beton und zähelastischem Stahl dar. Nur wenige veröffentlichte Arbeiten beschäftigen sich mit der Erforschung der trennenden Bearbeitung des umfangreich eingesetzten Konstruktionswerkstoffs Stahlbeton. Mit dieser Arbeit soll ein Beitrag zur Verbesserung des Prozessverständnisses für das...

This thesis presents the first LHCb measurement of 𝐶𝑃 violation in 𝐵0 → 𝐷∗±𝐷∓ decays. Due to the 𝑏 → 𝑐𝑐𝑑 transition, 𝐵0 → 𝐷∗±𝐷∓ decays give access to higher-order Standard Model contributions. The decay-time-dependent measurement is performed on a dataset corresponding to an integrated luminosity of 9 fb−1 recorded by the LHCb detector in proton-proton collisions at centre-of-mass energies of 7, 8 and 13 TeV. The 𝐶𝑃 observables are measured with an unbinned maximum likelihood fi...

In a world where service robots are increasingly becoming an inherent part of our lives, it has become essential to provide robots with superior perception capabilities and acute semantic knowledge of the environment. In recent years, the computer vision field has advanced immensely, providing rich information at a fraction of the cost. It has thereby become an essential part of many autonomous systems and the sensor of choice while tackling the most challenging perception problems. Neverth...

The development of innovative and convenient methods for efficient synthesis of C-glycosides could facilitate access to novel potent therapeutics. Distinct carbohydrate donors are useful precursors for direct C-C bond formation. Vinylogous dienolates, as one type of C-C bond formation substrates, can act as enabling chemical tools for introducing the desired motifs in an atom-economical and efficient manner. However, the vinylogous dienolates are underreported in C-glycosylation. The dev...

In the framework of Quality-by-Design (QbD), the inline determination of process parameters or quality attributes of a product using sufficient process analytical technology (PAT) is a center piece for the establishment of continuous processes as a standard pharmaceutical technology. In this context, Twin-Screw-Extrusion (TSE) processes, such as Hot-Melt-Extrusion (HME), are one key aspect of current research. The main benefit of this process technology is the combination of different unit op...

This dissertation deals with the problem of estimating the recurrence time of rare flood events, especially in the case of short data records. In such scenarios regional flood frequency analysis is used, a multi-step procedure with the goal of improving quantile estimates by pooling information across different gauging stations. Different aspects of regional flood frequency analysis using the Index Flood model are analysed, and improvements for parts of the procedure are proposed. In ...

Lösungsstrategien für Gemischt-Ganzzahlige Nichtlineare Programme (MINLPs) basieren häufig auf einer konvexen Relaxierung der zulässigen Menge. Diese Relaxierung wird benutzt um untere Schranken zu ermitteln und um die Qualität lokaler Lösungen zu beurteilen. In dieser Thesis diskutieren wir verschiedene Ansätze um geeignete Relaxierungen zu konstruieren und zu verbessern. Außerdem analysieren wir diese in Hinblick auf Strenge und Qualität der resultierenden unteren Schranken. Dabei betrachte...