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The European Union stands as a remarkable example of regional economic and political integration, fostering trade relationships among its member states through committing to joint laws and policies. Despite all the EU’s successes, it faces constant challenges. This thesis combines three chapters and reflects upon various dimensions of international trade within the EU. By applying theory consistent structural gravity estimations this thesis sheds light on the influence of converging and ...
Im Rahmen dieser Dissertation wird ein Verfahren zur Identifikation von Teilnetzen in der Mittelspannungsebene entwickelt. Die Besonderheit liegt vor allem in der adaptiven Implementierung und Erweiterung in Ortsnetzstationen durch den Einsatz von Virtualisierungslösungen und Algorithmen des maschinellen Lernens. Der Begriff Teilnetz beschreibt eine physikalisch vom Verbundsystem isolierte und von der Größe unbestimmte Versorgungsstruktur, welche aufgrund auftretender Störungen unbeabsichtig...
Der Schwerpunkt dieser Dissertation liegt auf der Entwicklung der Algorithmen und Software für stromsparende IoT-Geräte bezogen auf die Problematik der Rettungsgassenbildung auf Autobahnen mit autonomen Fahrzeugen. Auf den Autobahnen kommt es immer wieder zu unvorhersehbaren schwerwiegenden Unfällen. Dabei vergessen die Fahrer der Fahrzeuge teilweise eine Rettungsgasse für die Polizei- und Rettungsfahrzeuge zu bilden und behindern diese beim Erreichen des Unfallorts. Dabei ist für die Unfallb...
Memory capabilities in Deep Reinforcement Learning (DRL) agents have become increasingly crucial, especially in tasks characterized by partial observability or imperfect information. However, the field faces two significant challenges: the absence of a universally accepted benchmark and limited access to open-source baseline implementations. We present "Memory Gym", a novel benchmark suite encompassing both finite and endless versions of the Mortar Mayhem, Mystery Path, and Searing Spotligh...
Modern high energy physics experiments have increasing demands on particle detectors in terms of their spatial and temporal resolution, as well as their ability to withstand higher radiation levels. To meet these demands, increasingly complex detectors with ever smaller device segmentations are being developed that require precise device characterisation. This work is dedicated to a newly developed characterisation technique: the two photon absorption - transient current technique (TPA-T...
Consider a system in which a load exerted on it is equally shared between its components. Whenever one component fails, the total load is redistributed across the surviving components. This in turn increases the individual load applied to each of these components and therefore their risk of failure. Such a system is called a load sharing system. In a load sharing system, the failure rate of a surviving component grows with the number of failed components. However, the risk of failure is li...
Investor decision-making relies on accurate, timely information, but market efficiency theories and information asymmetry challenge the ability to outperform the market. Disclosure practices, including the emerging importance of ESG information, play a key role in shaping investor sentiment and market dynamics. Digital platforms, especially social media, have transformed how information is disseminated, influencing corporate disclosure practices and investor reactions. Behavioral finance high...
Data quality is an essential aspect of organizational data management and can facilitate accurate decision-making and building competitive advantages. Nu-merous data quality tools aim to support data quality work by offering automa-tion for different activities, such as data profiling or validation. However, de-spite a long history of tools and research, a lack of data quality remains an issue for many organizations. Data quality tools face changes in the organizational (e.g., evolving data a...
In this thesis, a novel approach to Monte Carlo event generator tuning, grounded in Bayesian reasoning, is presented. The Bayesian Analysis Toolkit (BAT.jl) is introduced as a modern tool for performing Bayesian inference. A numerical test suite that verifies the validity and performance of the BAT.jl package is developed. The test suite is used to evaluate the performance of the Markov chain Monte Carlo (MCMC) sampling algorithms implemented in BAT.jl, utilizing a selection of test functions...
This thesis focuses on developing a two-way coupled framework for the numerical simulation of fiber suspension flows. The influence of fibers on the flow is accounted for by evaluating a non-Newtonian stress term incorporated into the Navier-Stokes equations. The accuracy of the analysis depends on a second-order tensor field used to approximate the orientation distribution of fibers. In this context, the disperse phase can be treated in the Lagrangian or Eulerian manner. We conduct a compreh...
This is a thesis on query evaluation in parallel and distributed settings, and structurally simple rewritings. It consists of three parts. In the first part, we investigate the efficiency of constant-time parallel evaluation algorithms. That is, the number of required processors or, asymptotically equivalent, the work required to evaluate queries in constant time. It is known that relational algebra queries can be evaluated in constant time. However, work-efficiency has not been a focus, ...
The concept of sustainability is not new to Nepal and was accepted as early as the Brundtland Commission published its report in 1987. However, very few studies have been conducted to see the linkage between sustainable consumption and nature conservation, such as ecosystem-based adaptation (EbA), and no research was reported from Nepal. A mixed research method was applied which included primary data collection from household surveys, focus group discussions, key informant interviews and expe...
Research suggests that children with developmental dyscalculia (DD) have deficits in basic numerical skills. However, there is conflicting evidence on whether basic numerical skills in children with DD are qualitatively different from those in typically developing children (TD) or whether basic numerical skills development in children with DD is simply delayed. In addition, there are also competing hypotheses about deficits in basic numerical skills, assuming (1) a general deficit in represen...
The high-pressure behaviour of flexible zeolitic imidazolate frameworks (ZIFs) of the ZIF-62 family with the chemical composition M(im)2−x(bim)x is presented (M2+=Zn2+, Co2+; im−=imidazolate; bim−=benzimidazolate, 0.02≤x≤0.37). High-pressure powder X-ray diffraction shows that the materials contract reversibly from an open pore (op) to a closed pore (cp) phase under a hydrostatic pressure of up to 4000 bar. Sequentially increasing the bim− fraction (x) reinforces the framework, leading to an ...
We extend the scope of application for MCP-Mod (Multiple Comparison Procedure and Modeling) to in vitro gene expression data and assess its characteristics regarding model selection for concentration gene expression curves. Precisely, we apply MCP-Mod on single genes of a high-dimensional gene expression data set, where human embryonic stem cells were exposed to eight concentration levels of the compound valproic acid (VPA). As candidate models we consider the sigmoid Emax (four-parameter log...
We propose to use Bayesian optimization (BO) to improve the efficiency of the design selection process in clinical trials. BO is a method to optimize expensive black-box functions, by using a regression as a surrogate to guide the search. In clinical trials, planning test procedures and sample sizes is a crucial task. A common goal is to maximize the test power, given a set of treatments, corresponding effect sizes, and a total number of samples. From a wide range of possible designs, we aim ...
Can knowledge be defined? We expound an argument of John Cook Wilson's that it cannot. Cook Wilson's argument connects knowing with having the power to inquire. We suggest that if he is right about that connection, then knowledge is, indeed, indefinable.
Akt is a protein kinase that has been implicated in the progression of cancerous tumours. A number of covalent allosteric Akt inhibitors are known, and based on these scaffolds, a small library of novel potential covalent allosteric imidazopyridine-based inhibitors was designed. The envisaged compounds were synthesised, with click chemistry enabling a modular approach to a number of the target compounds. The binding modes, potencies and antiproliferative activities of these synthesised compou...
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- 291 Dette, Holger
- 138 Suter, Dieter
- 133 Böhmer, Roland
- 79 Weyer, Johannes
- 78 Leuders, Timo
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- 74 Schweizer, Ben
- 74 Ufer, Stefan
- 74 Weihs, Claus
- 73 Biehler, Rolf
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