In kritischen Situationen sind viele Fahrer von PKWs mit der Fahrzeugführungsaufgabe überfordert. Die Unfallzahlen konnten bis 2013 auch durch die Einführung von aktiven Fahrerassistenzsystemen wie ABS, ASR und ESC gesenkt werden. In den folgenden Jahren ist ein leichter Anstieg zu verzeichnen. Um die Unfallzahlen wieder zu senken, werden neue Fahrerassistenzsysteme benötigt, die neben fahrdynamischen Größen auch Informationen über das Fahrzeugumfeld miteinbeziehen. Dies kann durch assistiere...

Functional data analysis is typically conducted within the L2-Hilbert space framework. There is by now a fully developed statistical toolbox allowing for the principled application of the functional data machinery to real-world problems, often based on dimension reduction techniques such as functional principal component analysis. At the same time, there have recently been a number of publications that sidestep dimension reduction steps and focus on a fully functional L2-methodology. This pap...

The aim of this study is to investigate the mechanism of electro-acupuncture (EA) on the recovery of injured spinal cord. Rats were randomly divided into normal control, sham-operated, SCI, SCI+EA group and T10 segment spinal cord injury (SCI) rat model was established by the modified Allen’s method. After 7 days, the mRNA and protein expression of Nestin, neuron specific nuclear protein (NeuN) and calcitonin gene related peptide (CGRP) were detected by real time RT-PCR, Western blot and immu...

Bacteria belonging to the family Brevibacterieae are ubiquitous Gram positive organisms that are responsible for the feet odour and cheese aroma. Brevibacterium mcbrellneri is a relatively new member belonging to Brevibac- terieae. In the current manuscript we discuss isolation of biologically active metabolites from Brevibacterium mcbrellneri. Two aromatic esters were isolated from Brevibacterium mcbrellneri by “Bioassay guided fractiona- tion strategy” and identified as di-(2-ethylhexyl) ph...

This experimental study aimed to investigate the protective effect of a bioflavonoid, hesperidin (HP), on formal- dehyde (FA)-related pathophysiological and behavioral outcomes in pregnant rats and developmental aspects in their offspring. Female Wistar rats were subjected to perigestational exposure to FA (2 mg/kg/day per os) with a concomitant treatment with HP (50 mg/kg/day per os). Pregnant rats were weighed throughout gestation and tested in two behavioral paradigms (elevated plus-maze a...

Anti-colitis effect of antidepressants has been demonstrated recently. Doxepin, a tricyclic antidepressant drug (TCA), with potent H1, H2, alpha1 adrenergic and muscarinic receptor blocking effects could be a good candidate for investigation for its anti-colitis activity. Moreover high prevalence of depression in patients who suffer from IBD (inflammatory bowel disease), defends this idea that adjuvant therapy with an antidepressant drug which has anti-inflammatory effect, may exert favorable...

Oxidative stress due to excessive accumulation of reactive oxygen species (ROS) is one of the risk factors for the development of several chronic diseases. In this study, we investigated the protective effects of Scutellaria bai- calensis rhizome ethanol extract (SBRE) against oxidative stress-induced cellular damage and elucidated the un- derlying mechanisms in the HaCaT human skin keratinocyte cell line. Our results revealed that treatment with SBRE prior to hydrogen peroxide (H2O2) exposur...

Long non-coding RNAs (lncRNAs) have been found to show important regulatory roles in various human cancers. Lnc-RNA PANDAR is a novel identified lncRNA that was previously reported to show abnormal expression pattern in various cancers. However, little is known of its expression and biological function in thyroid cancer. Here, we used the quantitative real-time PCR (qRT-PCR) to determine the expression of PANDAR in 64 thyroid cancer tissues. We found that expression of PANDAR was up...

Rhus species are known in traditional medicine for their therapeutic virtue and their extracts showed numerous important properties including antimalarial, antimicrobial, antiviral, and hypoglycemic and anticonvulsant activi- ties. Rhus tripartitum (Ucria) is a medicinal plant widely used in Tunisia folk medicine against chronic diarrhea and gastric ulcer. This study was designed to examine in vitro and ex vivo antioxidant, anti-inflammatory and anticancer activities of four extract...

Sirtuin1 (SIRT1) and forkhead box transcription factor O subfamily 1 (FOXO1) play vital roles in the maintenance of hippocampal neuronal homeostasis during aging. Our previous study showed that melatonin, a hormone mainly secreted by the pineal gland, restored the impaired memory of aged mice. Age-related neuronal energy deficits contribute to the pathogenesis of several neurodegenerative disorders. An attempt has been made to determine whether the effect of melatonin is mediated th...

The purpose of the current study was to investigate the potential anti-obesity activity of an enzymatic hydrolysate of velvet antler in inhibiting adipogenesis in 3T3-L1 cells and in high-fat diet (HFD)-fed obese mice. The enzy- matic hydrolysate was prepared using the commercial food grade protease, Protamex. The velvet antler Protamex hydrolysate (VAPH) indicated profound inhibitory effects on adipogenesis dose-dependently by decreasing the accumulation of triglycerides and down-regulating ...

Kontextfreie Spiele sind ein formales Modell, welches in seiner einfachsten Form den Ableitungsmechanismus kontextfreier Grammatiken zu einem Spiel für zwei Spieler (genannt Juliet und Romeo) verallgemeinert; dabei wählt in einer gegebenen Satzform (d.h. einer Zeichenkette aus Terminal- und Nichtterminalsymbolen) jeweils Juliet ein zu ersetzendes Nichtterminalsymbol aus, worauf Romeo jeweils entsprechend den Ableitungsregeln entscheidet, wodurch dieses Nichtterminalsymbol ersetzt werden soll....

We present a new numerical scheme to solve the Helmholtz equation in a wave-guide. We consider a medium that is bounded in the x2-direction, unbounded in the x1-direction and ε-periodic for large |x1|, allowing different media on the left and on the right. We suggest a new numerical method that is based on a truncation of the domain and the use of Bloch wave ansatz functions in radiation boxes. We prove the existence and a stability estimate for the infinite dimensional version of the ...

Die stetig wachsende Weltbevölkerung sowie der steigende Lebensstandard ziehen eine Erhöhung der benötigten Produktionskapazitäten der chemischen Industrie nach sich. Neben den schwindenden Ressourcen resultiert hieraus ein weiterer belastender Aspekt, das erhöhte Abfallaufkommen. Aus diesem Grund fokussieren sich sowohl die Wissenschaft, als auch die chemische Industrie immer weiter auf das Konzept der Grünen Chemie, welches diesen Problemen, die aus den stetig wachsenden Anforderungen entst...

The present thesis addresses three key questions on commodity price movements: How can short-term commodity price changes be explained? What is the influence of financial speculation on commodity prices and what are the fundamental drivers of long-term commodity price developments? To answer those questions the thesis consists of three self-contained chapters. Chapter 2 adopts a one-sided representation of the generalized dynamic factor model to extract the common movement of thirty-one comm...

This thesis deals with the development of novel material models that capture the evolution of microstructures. The analysis of microstructures is essential for the description of metallic material properties, which are considered in this thesis. Depending on the underlying application, microstructures are analysed on the technological relevant macroscale or on the materials science relevant microscale. Independent of the underlying scale, mechanical and thermal loadings are the most dominatin...

Die Feuerverzinkung wird im Stahl- und Verbundhochbau seit etlichen Jahren als leistungsfähiger und robuster Korrosionsschutz eingesetzt. Schutzdauern von mehreren Jahrzehnten sind keine Seltenheit, wodurch der Korrosionsschutz über den Lebenszyklus des Bauwerks nahezu wartungsfrei ist. Im Brückenbau wurde jedoch bislang in der Regel auf organische Beschichtungssysteme mit einer Schutzdauer von nur ca. 30 Jahren gesetzt, obwohl Brücken mit 100 Jahren einen besonders langen, rechnerischen Lebe...