Das Ziel dieser Arbeit besteht darin, einen Beitrag dazu zu leisten, dass Kinder mit Hörbehinderung vor sexuellem Missbrauch geschützt werden. Mit dieser Zielperspektive soll unter einem theoretisch fundierten, empirischen Ansatz eine Forschungslücke geschlossen werden, indem ein evidenzbasiertes Präventionstraining für die pädagogische Arbeit mit Kindern mit Hörbehinderung erstens konzipiert und zweitens evaluiert wird. Dieses Präventionstraining wird als eine zentrale Möglichkeit betrachtet...

Understanding the contents of handwritten texts from document images has long been a traditional field of research in computer science. The ultimate goal is to automatically transcribe the text in the images into an electronic format. This would make the documents from which the images were generated much easier to access and would also allow for a fast extraction of information. Especially for historical documents a possibility to easily sift through large document image collections would...

The development of novel and efficient methods for the transition metal-free functionalization of inert and abundant C–H bonds offers striking advantages in terms of step- and atom economy under environmentally benign reaction conditions. Metal-free reactions serve as environmentally friendly substitutes for cost intensive and harmful transition metal-catalyzed reactions. However, oxidative coupling reactions under metal-free conditions face some unsolved problems. High molecular weight oxida...

Die Dissertation Kontrollkarten zur Alarmgebung in Stromnetzen entstand im Rahmen einer von der Deutschen Forschungsgemeinschaft geförderten Forschergruppe mit dem Schwerpunkt Schutz- und Leitsysteme zur zuverlässigen und sicheren elektrischen Energieübertragung (FOR 1511). Durch den Verfasser wurde die Möglichkeit einer automatisierbaren Überwachung eines elektrischen Energienetzes mittels statistischer Prozesskontrolle untersucht. Dazu standen Aufzeichnungen der Netzfrequenz aus fünf eu...

Today's state of the art within industrial applications requires the usage of efficient and high-performance materials, which are optimally designed in terms of production costs, material savings, fuel consumption or their mechanical behaviour. In many cases, a useful choice of materials of components contributes to the overall performance significantly. Modern materials can not be classified as homogeneous, but are composed of various ingredients. Often, considerations at the structural lev...

Platinhaltige Zytostatika, wie z. B. Cisplatin, werden in vivo durch eine Reihe von (bio-) chemischen Reaktionen verändert und metabolisiert. Die wichtigsten Prozesse dabei sind die intrazelluläre Hydrolyse und die Reaktion mit kleineren Nukleophilen oder Proteinen. Bezüglich des Verhaltens von Platinkomplexen im Cytosol sind einige Fragen weiterhin nur unbefriedigend geklärt, insbesondere hinsichtlich der Art und Bedeutung von Addukten des Platins mit intrazellulären Bindungspartnern. Im Ra...

There exist several multivariate extensions of the classical Sonine integral representation for Bessel functions of some index μ + v with respect to such functions of lower index μ. For Bessel functions on matrix cones, Sonine formulas involve beta densities β_(μ,v) on the cone and trace already back to Herz. The Sonine representations known so far on symmetric cones are restricted to continuous ranges Re μ, Re v > μ_0 where the involved Beta densities are probability measures and the limiti...

Multigrid methods belong to the best-known methods for solving linear systems arising from the discretization of elliptic partial differential equations. The main attraction of multigrid methods is that they have an asymptotically meshindependent convergence behavior. Multigrid with Vanka (or local multilevel pressure Schur complement method) as smoother have been frequently used for the construction of very effcient coupled monolithic solvers for the solution of the stationary incompre...

Cell adhesion and migration require a tightly regulated organization of cytoskeleton and cell-matrix adhesion sites which are large protein complexes consisted of multiple components. To address the question how the core focal adhesion (FA) proteins mediate the adhesion segregation process to form fibrillar adhesions (FB) and how they regulate cell motility, a high-content imaging screen was employed using combinatorial RNAi for 10 FA proteins. This revealed distinct FA proteins directly infl...

Surrogate models are crucial tools for many real-world optimization problems. An optimization algorithm can evaluate a data-driven surrogate model instead of an expensive objective function. While surrogate models are well-established in the continuous optimization domain, they are less frequently applied to more complex search spaces with discrete or combinatorial solution representations. The main goal of this thesis is to fill this gap. We develop and improve methods for data-driven su...

(Aminomethyl)ferrocene stellen eine wichtige Verbindungsklasse in Hinblick auf neuartige chirale Liganden dar und haben ihr chemisches Potential bei weitem noch nicht ausgeschöpft. Als Resultat der vorliegenden Arbeit können abhängig von Reaktionsbedingungen und zuvor eingeführten Substituenten selektiv unterschiedliche Positionen an beiden Ferrocenylringen angesteuert werden. Das enantiomerenreine ortho-lithiierte (Aminomethyl)ferrocen, zugänglich durch asymmetrische Metallierung, ist die S...

In this paper, death probabilities derived from the Gompertz and Wittstein models are used to project mortality at advanced ages beginning at the age of 101 years. Life table data of Germany from 1871 to 2012 serve as a basis for the empirical analysis. Projections of the death probabilities and life table survivors will be shown. The increase of the death probabilities slows down at very old ages. Finally, Wittstein´s formula will be regarded as a distribution function. Its reversed haz...

In this thesis, an approach is presented to probe the locations of track-like high energy starting events (HESE) for an additional clustering of neutrino events within six years of IceCube neutrino data at these positions. Two unbinned Likelihood stacking analyses using both a time-dependent, per-burst and a steady-state neutrino emission scenario are performed. This is done to be sensitive to a collection of weak fluxes, undetectable on their own and to test a rather broad regime of emi...

This cumulative dissertation examines the effectiveness of key audit matters (KAMs) in the auditor’s report. The first paper investigates whether KAMs contribute to the audit expectation gap. While standard setters and regulators suggest that the expanded auditor's report will be a lot clearer when KAM disclosure is included, researchers believe that the audit expectation gap is rather an educational gap which exists because financial statement users are not aware of auditor’s responsibilitie...