Opportunities and limits of ozonation as pre-treatment method for production waste water from pharmaceutical manufacturing See

During production of active pharmaceutical ingredients, process waste water is generated at several stages of manufacturing. Whenever possible, waste water will be processed by conventional waste water treatment plants. However, due to low biodegradability of pharmaceuticals or toxicity towards aquatic organisms, some waste water streams must be processed differently. For those, incineration constitutes the current method of choice. A main disadvantage of incineration is high consumption...

Public space in transition See

Teheran-ro in Seoul and Mediaspree area in Berlin are pristine examples for public spaces with a history of rapid change in the context of broader political and economic transitions. Dahae Lee shows that in such a transitional context, the public sector alone is incapable to provide and manage public space. Hence, it engages private sector entities in the form of privately owned public space/s (POPS). By analysing the planning instruments used for POPS in both cases, their uniqueness as well ...

Nuclear physics in proton therapy: new approaches for proton beam range verification using delayed gamma-rays See

In-vivo monitoring of the delivered dose is desirable in radiation therapy. Radionuclides generated during the proton irradiation can be used for imaging methods from nuclear medicine after the treatment session. In order to improve these techniques, this work focuses on three different aspects of nuclear physics from basic nuclear physics measurements to a clinical validation. The most relevant nuclear interaction is the production of C-11 from carbon as this nuclear interaction is used as a...

Comparative study on the efficiency of simulation and meta-model-based Monte Carlo techniques for accurate reliability analysis of corroded pipelines See

Estimation of the failure probability for corroded oil and gas pipelines using the appropriate reliability analysis method is a task with high importance. The accurate prediction of failure probability can contribute to the better integrity management of corroded pipelines. In this paper, the reliability analysis of corroded pipelines is investigated using different simulation and meta-model methods. This includes five simulation approaches, i.e., Monte Carlo Simulation (MCS), Directional Sim...

Predicting managers' mental health across countries: using country-level COVID-19 statistics See

Background: There is limited research focusing on publicly available statistics on the Coronavirus disease 2019 (COVID-19) pandemic as predictors of mental health across countries. Managers are at risk of suffering from mental disorders during the pandemic because they face particular hardship. Objective: We aim to predict mental disorder (anxiety and depression) symptoms of managers across countries using country-level COVID-19 statistics. Methods: A two-wave online survey of 406 manag...

Pressure is high – and rising See

COVID-19 pandemic and student reading achievement: findings from a school panel study See

Since 2020, the COVID-19 pandemic had an impact on education worldwide. There is increased discussion of possible negative effects on students’ learning outcomes and the need for targeted support. We examined fourth graders’ reading achievement based on a school panel study, representative on the student level, with N = 111 elementary schools in Germany (total: N = 4,290 students, age: 9–10 years). The students were tested with the Progress in International Reading Literacy Study instruments ...

Praktiken des Komponierens mit Loops und Samples See

Heteroleptische Dirhodium(II)-Komplexe und ihre Rolle als Katalysatoren in der asymmetrischen Cyclopropanierung mit α-metallierten Diazoverbindungen See

Die asymmetrische, intermolekulare Cyclopropanierung mit α-metallierten Diazoverbindungen ermöglicht die Darstellung von stereodefinierten α-metallierten Cyclopropanen. Diese sind wertvolle Bausteine für die Darstellung von Enantiomeren-angereicherten, strukturell vielfältigen Cyclopropanen. Ein neuartiger heteroleptische Dirhodium(II)-Komplex mit einem Amidat-Liganden weist eine einzigartige Reaktivität als Katalysator in dieser Cyclopropanierungsreaktion auf. Ursprünglich wurde dieser als V...

Labordidaktik in the making See

In den der kumulativen Dissertation zugrundeliegenden labordidaktischen Forschungsarbeiten wurden folgende drei übergeordneten Forschungsfragen bearbeitet: Vor welchen aktuellen und zukünftigen Herausforderungen steht das Lehren und Lernen in ingenieurwissenschaftlichen Fachlaboren? Wie lässt sich das Lehren und Lernen in den Fachlaboren theoretisch fassen und empirisch untersuchen? Wie lässt sich die Laborlehre anwendungs- und kompetenzorientierter gestalten, um den identifizierten Herausfor...

Local thermodynamic characterisation of binding sites and protein-ligand interactions See

With the advent of high-performance computing and progress in fields like structural biology, structure-based drug design (SBDD) has become an essential part in drug discovery projects. Yet, the automated de novo design of the “perfect” ligand to a protein structure remains unreached, even with today’s (re)emergence of powerful machine learning techniques. One of the reasons for this is the difficulty to consider all thermodynamically relevant details of protein-ligand complex formation in th...

Personal resources and leadership behavior See

This dissertation examines the role of leaders’ personal resources in the work-related context. The main goal is to explore the influence of leaders’ mindfulness and resilience on leadership behavior and employees’ work-related outcomes based on the integrative framework by Good et al. (2016). The first study explores leaders’ mindfulness and resilience as potential antecedents of servant and destructive leadership and the mediating effect of these leadership behaviors regarding employees’ tr...

Die Erhebung, Operationalisierung und Analyse von Aktionsräumen unter Nutzung von Befragungen See

Aktionsräume geben Aufschluss über die Nutzung räumlicher Infrastrukturen im Rahmen individueller Mobilität und eignen sich für vielfältige Untersuchungen über Wechselwirkungen zwischen Menschen und ihrer sozialen sowie räumlichen Umwelt. In quantitativen Erhebungen werden Aktionsräume unter anderem über Wegetagebücher, Tracking-Verfahren und Befragungen erfasst. Tracking-Verfahren und Wegetagebücher sind zwar präzise Instrumente zur Erfassung individueller Bewegungsmuster, erfordern für komp...

The silicon strip detector of the ATLAS Inner Tracker: from individual sensing units to multi-module petal structures See

Nowadays particle detector technology is taking big steps forwards and new devices dedicated to particle physics show very high performance. Particularly the semiconductor detectors have advanced significantly and are used for tracking purposes in the A Toroidal LHC ApparatuS (ATLAS) experiment at CERN thanks to their excellent spacial resolution: the compact size of the silicon and its high granularity allow to reach a precision measurement of few tens of microns. This thesis is focuse...

Models, unification, and simulations: Margaret C. Morrison (1954–2021) See

The philosophy of science community mourns the loss of Margaret Catherine Morrison, who passed away on January 9, 2021, after a long battle with cancer. Margie, as she was known to all who knew her, was highly regarded for her influential contributions to the philosophy of science, particularly her studies of the role of models and simulations in the natural and social sciences. These contributions made her a world-leading philosopher of science, instrumental in shifting philosophers' attenti...

Cross-cultural differences in academic self-efficacy and its sources across socialization contexts See

This study investigated how as reported by Bandura (Self-efficacy: The exercise of control Freeman, 1997) sources of self-efficacy differ across socialization contexts for German students with diverse immigrant backgrounds. We measured all four sources of academic self-efficacy in three socialization contexts for students of former Soviet Union and Turkish descent as well as without an immigrant background, assuming that we would find differences between these groups. Participants were 1217 s...

Potential impact assessment of climate-related hazards on urban public health services: interaction of changing climate-related hazards and urban development in the future, Khon Kaen City, Thailand See

Current understanding of the interactions between the future urban development change and climate change in the local context, considering infrastructure operation & functionality, is still primitive, especially in public health services. This study offers a climate-resilient operationalization framework for urban public health services considering the interaction between urban development change and climate change across scales, the so-called Health Integrative Climate Resilience and Adaptat...

Erwerb von vernetztem professionellem Wissen über Rechtschreibunterricht im Lehramtsstudium See

In der Professionalisierung von Deutschlehrkräften gelingt es nur mäßig Fachwissen und fachdidaktisches Wissen in der universitären Ausbildungsphase zu vermitteln. Zudem gelingt der Zugriff von Studierenden auf erworbenes Wissen in fachdidaktischen Anforderungssituationen kaum. Lehramtsstudierende sollen ein vernetztes professionelles Wissen aufbauen, um in professionellen Handlungssituationen explizit auf die Wissensinhalte zugreifen zu können. Ob der Aufbau solch eines Professionswissens in...

Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients See

While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise on the inflammation markers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic-immune-inflammation index (SII) and associations to patient-reported-outcomes in CCPs ...