Clinical trials often aim to compare a new drug with a reference treatment in terms of efficacy and/or toxicity depending on covariates such as, for example, the dose level of the drug. Equivalence of these treatments can be claimed if the difference in average outcome is below a certain threshold over the covariate range. In this paper we assume that the efficacy and toxicity of the treatments are measured as binary outcome variables and we address two problems. First, we develop a new test ...

This thesis is devoted to the study of mass effects in higher order radiative corrections within QED and QCD. The first part of the thesis deals with the process of deep-inelastic scattering. We compute the full mass dependence of the pure singlet Wilson coefficient in the polarized and unploarized case to next-to-leading order using iterated integrals over square root valued letters. Through explicit expansion in the asymptotic limit we proof the factorization of the heavy Wilson coefficie...

Dieses Promotionsvorhaben zentriert die Frühe (Medien-)Bildung sowie die Forschungs- und Themengebiete Migration und Interkulturalität, die in der Kindheitsforschung generell und kulturvergleichenden Kindheitsforschung speziell bislang nicht hinreichend berücksichtigt wurden. Der Fokus der vorliegenden Qualifikationsarbeit, die im Rahmen des interventiv angelegten, in Dortmund angesiedelten, Forschungsprojekts KidSmart – Medienkompetent zum Schulübergang (2010-2012) entstanden ist (vgl....

Resting heart rate (RHR) is positively related with mortality. Regular exercise causes a reduction in RHR. The aim of the systematic review was to assess whether regular exercise or sports have an impact on the RHR in healthy subjects by taking different types of sports into account. A systematic literature research was conducted in six databases for the identification of controlled trials dealing with the effects of exercise or sports on the RHR in healthy subjects was performed. The studies...

In the field of surface engineering, the use of self-lubricous coatings with the incorporation of vanadium represent a promising approach to reduce friction, thus contributing to the wear behavior. For vanadium containing hard coatings produced by means of thin film technology, the reduction in friction at elevated temperatures was repeatedly attributed to temperature-induced and tribo-oxidatively formed oxides which act as solid lubricant. Only very few studies focused on the tribological ch...

Direct Behavior Rating (DBR) as a behavioral progress monitoring tool can be designed as longitudinal assessment with only short intervals between measurement points. The reliability of these instruments has been mostly evaluated in observational studies with small samples based on generalizability theory. However, for a standardized use in the pedagogical field, a larger and broader sample is required in order to assess measurement invariance between different participant groups and over tim...

Computer-based testing (CBT) is gaining importance for studies addressing the diagnosis of competencies, because it is possible to simulate authentic action situations and may reduce the effort of analyzing the data. This benefit is most important for the phase of item design. In this phase of assessment construction, the pattern of answers of a sample is used to draw conclusions on the functionality of the items. Currently, there are no standards for the encodement of items which consider th...

In the one-step manufacturing process for fiber metal laminate parts, the so-called in situ hybridization process, the fabrics are interacting with metal blanks. During deep drawing, the liquid matrix is injected between the metal sheets through the woven fiber layers. The metal blanks can be in contact with dry or with infiltrated fibers. The formability of the blanks is influenced by the variation of the starting time of injection. The reason for that is that, due to high contact forces, th...

Magnesium (Mg)-based biomaterials are promising candidates for bone and tissue regeneration. Alloying and surface modifications provide effective strategies for optimizing and tailoring their degradation kinetics. Nevertheless, biocompatibility analyses of Mg-based materials are challenging due to its special degradation mechanism with continuous hydrogen release. In this context, the hydrogen release and the related (micro-) milieu conditions pretend to strictly follow in vitro standards bas...

Das Innenrundschälschleifen mit galvanisch gebundenen CBN-Schleifscheiben ist ein hocheffizientes Fertigungsverfahren der Bohrungsbearbeitung von gehärteten Stählen. Durch hohe Schleifscheibengeschwindigkeiten können beim Innenrundschleifen hohe Zeitspanvolumina realisiert werden. Trotz seiner Vorzüge stellt das Verfahren aufgrund der komplexen Eingriffsverhältnisse eine große Herausforderung in seiner Prozessbeherrschung dar. Um die Vorteile des Verfahrens prozesssicher und wirtschaftlich e...