Study of total synthesis of 9α,10β- Bisangeloyloxy-7-epi-3E-agerafastin and 3-O- Feruloylcassine by copper-mediated nucleophilic substitution and gold-catalyzed cycloisomerization See

In this dissertation, the main work is the synthesis of 6-membered heterocyclic natural products by using the synthetic methods developed in our group, i.e. the copper-mediated nucleophilic substitution for synthesizing functionalized allenes, as well as, the gold-catalyzed cycloisomerization of functionalized allenes for synthesizing heterocycles. Chapter 2 demonstrates the journey of the first total synthesis of 9α,10β-Bisangeloyloxy-7 - epi- 3E- agerafastin including the racemic synthesis...

Gold-katalysierte Mehrkomponentenreaktionen zur Darstellung spirocyclischer Pyrazolidine See

Ein einfacher Zugang zu komplexen Molekülen ist nicht nur für die Organische Chemie, sondern auch für die Wirkstoffentwicklung der pharmazeutischen Industrie von großem Interesse. In diesem Zusammenhang stellen Mehrkomponentenreaktionen ein nützliches Werkzeug für die Synthese diverser hochsubstituierter Verbindungen dar. Diese Arbeit beschäftigt sich mit der Synthese von funktionalisierten heterocyclischen Spiroverbindungen. Diese werden mittels Gold-Katalyse in einer Mehrkomponentenreakti...

Essays zum Mittelstand – Auswirkungen von Finanzierungsbeschränkungen, IFRS und CSR-RLUG See

Asymptotic class numbers of lattices See

We study the frequency of two- and three-dimensional integral lattices with a given automorphism group G. We estimate the number of isomorphism classes H(D) of lattices with determinant at most D. A general approach is given by counting the possible reduced Gram matrices of lattices. If the underlying reduction theory admits only one reduced lattice per isomorphism class, this gives us H(D). We use the fact that D implies bounds on the entries of the Gram matrix. We have to evaluate multip...

Analytical and simulation-based prediction of surface roughness for micromilling hardened HSS See

The high quality demand for machined functional surfaces of forming tools, entail extensive investigations for the adjustment of the manufacturing process. Since the surface quality depends on a multitude of influencing factors in face micromilling, a complex optimization problem arises. Through analytical and simulative approaches, the scope of the experimental investigation to meet the requirements for surface roughness can be significantly reduced. In this contribution, both analytical and...

Interleukin 6 (rs1800795) gene polymorphism is associated with cardiovascular diseases See

Cardiovascular diseases (CVD) are group of complex and multifactorial pathologies, in which interleukin-6 (IL- 6) gene polymorphisms have been associated with several components of the CVD. Thus, in this study, we thoroughly reviewed and meta-analyzed evidence on the association between the IL-6 (rs1800795) gene polymorphism and CVD. We systematically searched in the PubMed, Web of Sciences, and Scopus databases. The analyses were performed using five study groups based on (1) a combined poo...

In vivo administration of G9a inhibitor A366 decreases osteogenic potential of bone marrow-derived mesenchymal stem cells See

Epigenetic mechanisms such as histone methylation are considered as one of the most important mediators that control stem cell behaviors such as proliferation, senescence and differentiation. G9a, a histone methyltransferase, has recently generated intense attention as potential target for controlling many diseases such as cancers. The aim of the present study was to evaluate the effect of in vivo administration of A366, a G9a inhibitor, on proliferative and differentiation potential of bone ...

Association between four microRNA binding site-related polymorphisms and the risk of warfarin-induced bleeding complications See

Bleeding is the most serious complication of warfarin anticoagulation therapy and is known to occur even at patients with therapeutic international normalized ratio (INR) range. Recently, it has been shown that microRNAs play a significant role in pharmacogenetics by regulating genes that are critical for drug function. Interaction between microRNAs and these target genes could be affected by single-nucleotide polymorphisms (SNPs) located in microRNA-binding sites. This study focused on 3′-un...

Development and validation of a new scale for prediction of low back pain occurrence among nurses See

There are several scales for prediction of low back pain (LBP) occurrence, but most of them only consider occupational aspect. This study aimed to develop and validate a new biopsychosocial scale for the LBP prediction among nurses. In this mixed-method study, a scale was developed by integrating the findings from the literature review and the semi-structured interviews. The qualitative and quantitative face and content validation were then performed. The construct validation was performe...

Improvement of the LHCb measurement of sin(𝟮𝞫) in additional 𝘽𝟬 decay modes See

This thesis presents the measurement of decay-time-dependent 𝐶𝑃 violation in the decays of 𝐵0 → 𝜓(2𝑆)𝐾S0 and 𝐵0 → 𝐽/𝜓𝐾S0 using data collected with the LHCb experiment in 𝑝𝑝 collisions at centre-of-mass energies of 7 TeV and 8 TeV, corresponding to a total integrated luminosity of 3 fb−1. In both considered decay modes, the 𝐾S0 meson is reconstructed from two charged pions, while the 𝜓(2𝑆) meson is reconstructed from two muons, whereas the 𝐽/𝜓 meson is reconstructed from...

A generalized method of moments estimator for structural vector autoregressions based on higher moments See

I propose a generalized method of moments estimator for structural vector autoregressions with independent and non-Gaussian shocks. The shocks are identified by exploiting information contained in higher moments of the data. Extending the standard identification approach, which relies on the covariance, to the coskewness and cokurtosis allows to identify and estimate the simultaneous interaction without any further restrictions. I analyze the finite sample properties of the estimator...

Supplement zu Entwicklung eines Verfahrens zur Herstellung von tiefen nicht kreisförmigen Bohrungen See

Supplement zu Entwicklung eines Verfahrens zur Herstellung von tiefen nicht kreisförmigen Bohrungen See

Supplement zu Entwicklung eines Verfahrens zur Herstellung von tiefen nicht kreisförmigen Bohrungen See

Supplement zu Entwicklung eines Verfahrens zur Herstellung von tiefen nicht kreisförmigen Bohrungen See

Supplement zu Entwicklung eines Verfahrens zur Herstellung von tiefen nicht kreisförmigen Bohrungen See

Supplement zu Entwicklung eines Verfahrens zur Herstellung von tiefen nicht kreisförmigen Bohrungen See

Stiftungen, Zivilgesellschaft und soziale Differenz See

Supplement zu Innenkonturieren und Walzen tiefgebohrter Grundbohrungen See