Viruses transmitted by arthropods (arboviruses) are the etiological agents of several human diseases that have worldwide distribution; some of them are dengue (DENV), zika (ZIKV), yellow fever (YFV), and chikungunya (CHIKV) viruses. All of them are especially important in tropical and subtropical regions; however, zika and chikungunya viruses are involved in epidemics worldwide, while the dengue virus is still the biggest problem in public health in Latin America, with distribution in almost ...

In der vorliegenden Arbeit wird eine ganzheitliche Methode zur Simulation der instationären Wechselwirkungen zwischen Fluidenergiemaschinen und Anlagen entwickelt. Diese umfasst eine nichtreflektierende Randbedingung für eindimensionale numerische Domains sowie eine nichtreflektierende Kopplungsbedingung zur zeitechten Zwei-Wege-Kopplung von eindimensionalen und dreidimensionalen numerischen Domains. Mithilfe der entwickelten nichtreflektierenden Rand- und Kopplungsbedingung lässt sich sowohl...

In recent years, additive manufacturing methods such as Fused Layer Modeling have been continuously improved by industry and research institutions. In many cases, the influence of process control on the mechanical component properties is being investigated. Influencing parameters include the infill and its orientation as well as patterns. Extrusion parameters such as the volume flow, which can be influenced by the speed, the line width, and the layer thickness, and the temperatures, which det...

Gene therapy became in last decade a new emerging therapeutic era showing promising results against different diseases such as cancer, cardiovascular diseases, diabetes, and neurological disorders. Recently, the genome editing technique for eukaryotic cells called CRISPR-Cas (Clustered Regulatory Interspaced Short Palindromic Repeats) has enriched the field of gene surgery with enhanced applications. In the present review, we summarized the different applications of gene surgery for treating ...

To our knowledge, in spite of several trials exploring the beneficial effect of n-3 polyunsaturated fatty acids (PUFA) on polycystic ovary syndrome (PCOS), no comprehensive evidence has investigated the effects of n-3 PUFA consumption on PCOS complications. Therefore, our aim was to conduct a review to investigate the possible effect and related mechanisms. A comprehensive systematic search was conducted in Embase, MEDLINE/PubMed, Google Scholar, and SCOPUS, to identify studies investigating ...

The oral cavity and its appendices are exposed to considerable environmental and mechanical stress. This frequently involves cell junctions, which are goalkeepers of tissue homeostasis. Among those, gap junctions permit the exchange of compounds between cells, thereby controlling processes such as cell growth and differentiation. Tight junctions restrict paracellular transportation and inhibit movement of integral membrane proteins between the different plasma membrane poles. Adherens junctio...

Toxoplasma gondii (T. gondii) is an obligate intracellular parasite with worldwide distribution. It is estimated that near one-third of the people around the globe are latently seropositive for the parasite. Since the current common drugs are incapable in the elimination of parasites within tissue cysts, the development of an effective vaccine has high priority for researchers to limit the infection. During recent years, non-stop efforts of scientists have made great progress in the identific...

The residual stress state of a sheet metal component manufactured by metal forming has a significant influence on the mechanical properties, and thus determines the time until the component fails, especially for dynamic loads. The origin of the resulting residual stress state of incrementally formed parts with regard to the forming mechanisms of shearing, bending, and the normal stress component is still under investigation. The relationship between the process parameters, the forming mechani...

Primary human hepatocytes (PHHs) remain the gold standard for in vitro investigations of xenobiotic metabolism and hepatotoxicity. However, scarcity of liver tissue and novel developments in liver surgery has limited the availability and quality of tissue samples. In particular, warm ischemia shifts the intracellular metabolism from aerobic to anaerobic conditions, which increases glycogenolysis, glucose depletion and energy deficiency. Therefore, the aim of the present study was to investiga...

When examining patients with acute inflammatory respiratory diseases, it is difficult to distinguish between infectious pneumonia and interstitial pneumonia and predict patient prognosis at the beginning of treatment. In this study, we assessed whether endothelial selectin (E-selectin) predicts the outcome of patients with acute inflammatory respiratory diseases. We measured E-selectin serum levels in 101 patients who were admitted to our respiratory care unit between January 2013 and Decembe...

Accumulating evidence indicates that miR-9-5p plays an important role in several diseases, especially tumor progression. In this study, we investigated the clinical significance and biological function of miR-9-5p in prostate cancer (PCa). Using quantitative real time PCR (qRT-PCR) analysis, we found miR-9-5p level was significantly down-regulated in PCa tissues and cell lines. The decreased miR-9-5p expression was associated with tumor size, preoperative PSA, Gleason score and lymph node met...

Modern automotive systems integrate a variety of electrical and electronic components. To estimate the radiated emissions, the standard CISPR 25 describes the absorber-lined shielded enclosure (ALSE) method, which is the most important standardized field measurement method. However, it suffers from the need for a large anechoic chamber. To reduce costs and more conveniently integrate radiated emission investigations into the product design cycle, alternative methods that predict emissions wit...

Die Datenvernetzung innerhalb des Fahrzeuges hat Einfluss auf das Gewicht, das Volumen und die Komplexität des Fahrzeugkabelbaums. Mit den traditionellen Kfz-Bussystemen und der großen Vielfalt an Funktionen, die in Zukunft noch zunehmen wird, lässt sich ein Optimum hinsichtlich dieser Kriterien nur schwer erreichen. Eine mögliche Lösung könnte die Datenübertragung über das Kfz-Energiebordnetz darstellen. Die sogenannte Powerline Communication (PLC) ist eine Technologie, die die vorhandenen E...

The thesis at hand deals with the modelling of heat input and mass deposition during thermal spraying and especially with the capturing of the effective material behaviour of microstructures under consideration of inelasticity in the framework of thermo-mechanical continua. The heat input during thermal spraying is modelled by means of convective heat transfer as well as radiation in the framework of a non-linear rigid heat conductor which is implemented into a finite element programme. This ...

Marcetia taxifolia is a neotropical plant present in South America and it has been evaluated in several biological models due to the presence of active metabolites. Nevertheless, there is a limited quantity of studies related to the antiviral activity of the compounds present in this genus. In our work, the antiviral effect of the compounds isolated from the aerial parts of Marcetia taxifolia was evaluated against Hepatitis B virus (HBV), Herpes Simplex Virus type 1 (HSV-1), and Poliovirus ty...

Das Ziel der Jahresabschlussprüfung liegt in der Abgabe eines hinreichend sicheren Urteils über die Verlässlichkeit und damit die Ordnungsmäßigkeit des Jahresabschlusses unter Beachtung des Grundsatzes der Wirtschaftlichkeit. Infolge des aus der Digitalisierung resultierenden Anstiegs der jährlichen Geschäftsvorfälle sowie der wachsenden Komplexität der IT-Systemlandschaften auf der Mandantenseite sehen sich Abschlussprüfer zunehmend einer enormen Datenflut ausgesetzt und die Erreichung diese...

Accumulating evidence suggests that epigenetic mechanisms play an important role in the formation and maintenance of memory within the brain. Moreover, the effect of parental drug-exposure before gestation on behavioral state of offspring has been little studied. The main objective of the current study is to evaluate the effect of parental morphine exposure on avoidance memory, morphine preference and anxiety-like behavior of offspring. The total of 32 males and 32 females were used for matin...

Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine abundantly present at the feto-maternal interface proposed to play a role in establishment of pregnancy. We have previously shown that pharmacological inhibition of enzymatic activity of MIF decreases extravillous trophoblast invasion and migration in vitro. This study aimed to further elucidate potential role of endogenous trophoblast MIF, and to assess its importance for endovascular trophoblast cell function in part...