In this thesis, three different topics regarding the calculation of alert concentrations are considered. In toxicology, an alert concentration is the concentration where the response variable of interest attains or exceeds a pre-specified threshold. The first topic, handling deviating control values, considers cytotoxicity data. Often, response values for the lowest tested concentrations and the negative control do not coincide. This leads to the inability to properly interpret or even calcu...

The article explores the relation between personal identity and life-changing decisions such as the decision for a certain career or the decision to become a parent. According to L.A. Paul (Paul 2014), decisions of this kind involve “transformative experiences”, to the effect that - at the time we make a choice - we simply don’t know what it is like for us to experience the future situation. Importantly, she claims that some new experiences may be “personally transformative” by which she mean...

This contribution presents a novel probabilistic approach for the generation of discretionary lane change proposals with a focus on highway driving situations. The developed model is based on the quantification of the utility of driving lanes. It generates a lane change proposal if the current driving lane is unsatisfactory in the sense that the desired velocity of the automated vehicle is undershot because of a slow preceding vehicle. A driving simulator study was conducted to create a datas...

Measuring mutual fund managers’ skills by Microsoft’s TrueSkill algorithm, we find highly skilled managers to behave self-confident resulting in higher risk-taking in the second half of the year compared to less skilled managers. Introducing the TrueSkill algorithm, which is widely used in the e-sports community, to this branch of literature, we can replicate previous findings and theories suggesting overconfidence for mid-years winners.

An isotropic gradient-enhanced damage model is applied to shape optimisation in order to establish a computational optimal design framework in view of optimal damage distributions. The model is derived from a free Helmholtz energy density enriched by the damage gradient contribution. The Karush–Kuhn–Tucker conditions are solved on a global finite element level by means of a Fischer–Burmeister function. This approach eliminates the necessity of introducing a local variable, leaving only the gl...

Recommender systems are tools that support online users by pointing them to potential items of interest in situations of information overload. In recent years, the class of session-based recommendation algorithms received more attention in the research literature. These algorithms base their recommendations solely on the observed interactions with the user in an ongoing session and do not require the existence of long-term preference profiles. Most recently, a number of deep learning-based (“...

The aim of this paper is to improve the shape of specimens for biaxial experiments with respect to optimal stress states, characterized by the stress triaxiality. Gradient-based optimization strategies are used to achieve this goal. Thus, it is crucial to know how the stress state changes if the geometric shape of the specimen is varied. The design sensitivity analysis (DSA) of the stress triaxiality is performed using a variational approach based on an enhanced kinematic concept that offers ...

After four decades of research and development on language in mathematics classrooms, there is consensus that enhancing language is crucial for promoting students’ mathematics learning. After briefly sketching the theoretical contexts for work on this topic, in this paper we present six design principles for instruction that enhances language for mathematics learning. We then review the research that provides an empirical foundation for these principles, (a) concerning the design of learning ...

Die geminale Hydrierung von internen Alkinen generiert Ruthenium-stabilisierte Carbenkomplexe durch Übertragung von zwei Wasserstoffatomen auf ein und dasselbe Kohlenstoffatom eines Alkins. Diese neuartige Hydrierungsreaktivität wurde erst im Jahr 2015 entdeckt und in dieser Doktorarbeit umfassend untersucht. Es wurde demonstriert, dass das Ruthenium-Cyclopentadienylbasierte Katalysatorsystem durch elektronische Modifikation am Ligandensystem die geminale Hydrierung bevorzugen kann. Weiterhin...

In this study, poor readers in second school year were selected from three schools (n = 32). Their reading skills were surveyed weekly using a CBM instrument over one school semester. Furthermore, they were supported by a five-week reading fluency instruction. The majority of students increased their weekly learning growth in regular teaching and in the phase with the additive instruction. The weekly learning growth was higher in the phase with the additive instruction in reading syllables (b...

Hintergrund: Die Pilotstudie „Gesundheit und Unterstützung in Zeiten von Corona“ (Technische Universität Dortmund) erhob vom Mai bis Juli 2020 Veränderungen von Unterstützung und Wohlbefinden Älterer infolge der COVID-19-Pandemie. Ziel der Arbeit: Ziel war es, empirische Erkenntnisse zu den sozialen und mentalen Folgen der Pandemie für in Privathaushalten lebende Personen der Altersgruppe 40+ Jahre zu gewinnen. Betrachtet wurden durch die Pandemie bedingte Änderungen im Erhalt und im L...

Purpose: This work proposes an in-silico screening method for identifying promising formulation candidates in complex lipid-based drug delivery systems (LBDDS). Method: The approach is based on a minimum amount of experimental data for API solubilites in single excipients. Intermolecular interactions between APIs and excipients as well as between different excipients were accounted for by the Perturbed-Chain Statistical Associating Fluid Theory. The approach was applied to the in-silic...

The present study uses a quasi-experimental design to investigate the impact of team preferences on the accuracy of offside judgments. In Experiments 1 and 2, supporters of two German soccer clubs (i.e., Borussia Dortmund and FC Schalke 04) judged offsides in artificial scenes from a match between the clubs. We expected that supporters of both clubs would less frequently report the offside position of a forward from the preferred team. The results of Experiment 1 partly confirmed the predicti...

Joint academic–industrial projects supporting drug discovery are frequently pursued to deploy and benchmark cutting-edge methodical developments from academia in a real-world industrial environment at different scales. The dimensionality of tasks ranges from small molecule physicochemical property assessment over protein–ligand interaction up to statistical analyses of biological data. This way, method development and usability both benefit from insights gained at both ends, when predictivene...

Inwiefern der Besuch unterschiedlicher Schulformen Lernen und Bildungsverläufe beeinflusst, ist ein vieldiskutiertes Thema. Arbeiten zu Effekten der Schulformen für den Erfolg auf dem Arbeitsmarkt liegen jedoch bislang nur wenige vor. Hier setzt der vorliegende Beitrag an, in dem in einer längsschnittlichen Perspektive (N = 5292 Personen) überprüft wird, welche Effekte der Besuch unterschiedlicher Schulformen in der Sekundarstufe (vom Beginn der 7. Klasse) auf spätere berufliche Merkmale (Ber...