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Digitale Medien sind im Leben von Menschen mit und ohne Behinderung allgegenwärtig. Für eine gesellschaftliche Teilhabe ist es die Aufgabe der inklusiven Bildung, einerseits allen Schüler*innen Lernmöglichkeiten zum Erwerb schulischer Medienkompetenzen bereitzustellen und andererseits die Lernumgebungen so zu gestalten, dass sie sich an die individuellen Bedürfnisse der Schüler*innen anpassen. Dieses Lehrbuch stellt zentrale Lerntheorien im Kontext digitaler Medienarbeit vor und geht dabei ei...
During embryonic development, many cell types arise from a single homogenous cell population. Coordination via cell-cell signaling leads to functional specialization by changing the set of expressed genes. In very early mammalian development, the homogenous cell population of pluripotent cells in the inner cell mass breaks symmetry and differentiates into epiblast and primitive endoderm lineages under the influence of Fibroblast Growth Factor (FGF), Wingless Integrated (Wnt), and mammalian Ta...
Iron-sulfur (FeS) clusters are essential cofactors found in all living organisms. Acting as versatile electron carriers they are indispensable for life-sustaining processes, contributing to respiration, nitrogen fixation, and hydrogen production. Several proteins containing single and multiple FeS clusters are involved in the pathway to hydrogen evolution. Electron paramagnetic resonance (EPR) spectroscopy was used to characterize their FeS clusters providing valuable information about their ...
Die affektive Störung Depression zählt zu den häufigsten mentalen Erkrankungen weltweit. Die Versorgungsstruktur für Betroffene ist in Deutschland jedoch als nicht ausreichend einzustufen. Im Zuge der fortschreitenden Digitalisierung versprechen telepsychiatrische Angebote eine vielversprechende Lösung für Probleme herkömmlicher Behandlungsmethoden. Obwohl eine vergleichbare Wirksamkeit dieser Angebote wissenschaftlich gut dokumentiert ist, ist noch nicht ausreichend geklärt, ob diese Angebot...
The concept of GI, multi-stakeholder participation and resilient cities has emerged as a new dimension of sustainable urban development for green growth - leading to the strengthening of the resilience of the urban eco-system. Since Pakistan is undoubtedly at high risk to climate change and its impacts, especially flooding, makes the region vulnerable to in-daunting climatic catastrophes, the northwestern areas of Khyber Pakhtunkhwa (KP) province were no exception, gives evidence of the high ...
Das Thema Digitalisierung hält Einzug in fast alle Bereiche des Lebens. Ob Smartphone, Sprachassistent oder robotergesteuerte Produktionsmaschinen. Der digitale Wandel ist rasant und erfordert von der Gesellschaft und ihren Akteur*innen sich stetig an neue, schnellere und oftmals komplexere technologische Umgebungen anzupassen und mit ihnen zu interagieren. Durch diesen Umstand ist auch der Lebensbereich „Arbeit“ von der Digitalisierung umfassend betroffen. Die Digitalisierung einzelner oder ...
In diesem Working-Paper werden die Ergebnisse einer breit angelegten Analyse der deutsch- und englischsprachigen Fachliteratur zu Themen der industriellen Verdrängung und gewerblichen Gentrifizierung vorgestellt. Die Analyse erfolgte im Rahmen des DFG geförderten Forschungsvorhabens „The Big Sort. Funktionale Entmischungsprozesse in der reurbanisierten Stadtregion“, welches seit Januar 2023 an der TU Dortmund (Fakultät Raumplanung, Fachgebiet Stadtentwicklung) bearbeitet wird. Thematisiert we...
Mobility researchers acknowledge the multifaceted nature of individuals' trans-portation choices, influenced by personal attitudes, social norms, and transport infrastructure. However, the complexity of these factors often leads to incon-sistent findings in existing methodologies. Given the significant environmental impact of motorized private transportation, understanding the mechanisms of travel mode choice is imperative for fostering sustainable mobility behaviour. This paper introduces t...
Uncertainty quantification is an important task in machine learning - a task in which standard neural networks (NNs) have traditionally not excelled. This can be a limitation for safety-critical applications, where uncertainty-aware methods like Gaussian processes or Bayesian linear regression are often preferred. Bayesian neural networks are an approach to address this limitation. They assume probability distributions for all parameters and yield distributed predictions. However, training an...
Stochastic Model Predictive Control (SMPC) is a promising solution for controlling multivariable systems in the presence of uncertainty. However, a core challenge lies in obtaining a probabilistic system model. Recently, multi-step system identification has been proposed as a solution. Multi-step models simultaneously predict a finite sequence of future states, which traditionally involves recursive evaluation of a state-space model. Particularly in the stochastic context, the recursive evalu...
There are significant advances in GNSS-free cross-modality self-localization of self-driving vehicles. Recent methods focus on learnable features for both cross-modal global localization via place recognition (PR) and local pose tracking, however they lack means of combining them in a complete localization pipeline. That is, a pose retrieved from PR has to be validated if it actually represents the true pose. Performing this validation without GNSS measurements makes the localization problem ...
Mitigating outage regions is of particular interest for emerging millimeter-wave (mmWave) and future sub-terahertz frequency cellular networks. Whereas smart radio environments based on metasurfaces constitute a key concept for 6G research, current networks cannot be served as new control procedures are required. Although small prototypes are already emerging, costs will be higher for the dense deployment of reconfigurable intelligent surfaces (RISs) compared to passive reflectors. It is argu...
The ongoing changes in modern power systems towards increasingly decentralized systems render the coordination of generation assets and the corresponding dependency on Information and Communication Technology highly relevant. This work demonstrates the impact of three types of ICT errors, namely delayed data, data loss and data corruption, on the control of distributed energy resources in an active distribution network. The settling time of the active power response at the interconnection poi...
Nowadays, web applications are ubiquitous. Entire business models revolve around making their services available over the Internet, anytime, anywhere in the world. Due to today’s rapid development practices, software changes are released faster than ever before, creating the risk of losing control over the quality of the delivered products. To counter this, appropriate testing methodologies must be deeply integrated into each phase of the development cycle to identify potential defects as ear...
Aspartic proteases play a crucial role in human physiology and pathologyincluding as biomarkers for breast cancer and Alzheimer's disease, and as potential drug targets for infectious diseases. However, chemical probes for photoaffinity labeling (PAL) of these proteases are underdeveloped. We develop a full on-resin synthesis of clickable PAL probes based on the natural product inhibitor pepstatin, incorporating a minimal diazirine photo-reactive group. The positioning of this group in the i...
Silicon vacancies in silicon carbide (SiC) have been proposed as interesting candidates for quantum technology applications such as quantum sensing and quantum repeaters. SiC exists in many polytypes with different plane stacking sequences, and in each polytype, the vacancies can occupy a variety of different lattice sites. In this work, we focus on the three important charged silicon vacancies in the 6H-SiC polytype. We record the photoluminescence and continuous-wave optically detected magn...
Regarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has on the distribution of MT lengths in the two regimes of bounded and unbounded growth. We show that in the former case, the steady state length distribution is non-exponential and has a lighter tail if multiple steps are required to undergo a c...
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- 291 Dette, Holger
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- 133 Böhmer, Roland
- 80 Weyer, Johannes
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- 74 Schweizer, Ben
- 74 Ufer, Stefan
- 74 Weihs, Claus
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