Urban waterscapes are today a key element of revitalization strategies as locations for highscale office and housing estates as well as tourism and leisure amenities. Their renaissance is not only related to economic transformations; it also goes hand in hand with the re-establishment of urban waterscapes as important parts of the urban imagery and identity after years of neglect and ecologic devastation. We argue that new urban waterscapes have been and are being constructed as emblematic pl...

This paper is concerned with the state-constrained optimal control of the threedimensional thermistor problem, a fully quasilinear coupled system of a parabolic and elliptic PDE with mixed boundary conditions. This system models the heating of a conducting material by means of direct current. Local existence, uniqueness and continuity for the state system as well as existence of optimal solutions, admitting global-in-time solutions, to the optimization problem were shown in the the companion ...

In this thesis we propose a coordinate ascent method for a class of semidefinite programming problems arising in the reformulation of non-convex quadratic optimization problems where the variables are restricted to subsets of the integer numbers. It is known that non-convex quadratic integer problems are NP-hard for two reasons: the non-convexity of the objective function and the restrictions of integrality on the variables. Therefore no polynomial time algorithm is known for solving this cl...

Die in Australien beheimatete Pflanzengattung Duboisia, die historisch schon von den Aborigines verwendet wurde, ist bis heute die Hauptquelle der medizinisch genutzten Tropanalkaloide. Davon werden Scopolamin und dessen Derivate häufig als anticholinerge Wirkstoffe in der Behandlung von postoperativer Übelkeit und Erbrechen, Reiseübelkeit sowie gastrointestinalen, renalen und biliären Krämpfen angewandt. Bis heute wird die globale Marktversorgung mit Scopolamin hauptsächlich über den großflä...

The aim of present paper is to establish the detailed numerical results for bioconvection boundary-layer flow of two-phase dusty nanofluid. The dusty fluid contains gyrotactic microorganisms along an isothermally heated vertical wall. The physical mechanisms responsible for the slip velocity between the dusty fluid and nanoparticles, such as thermophoresis and Brownian motion, are included in this study. The influence of the dusty nanofluid on heat transfer and flow characteristics are i...

This paper addresses the problem of determining cost-minimal process designs for ideal multi-component distillation columns. The special case of binary distillation was considered in former work. Therein, a problem-specific bound-tightening strategy based on monotonic mole fraction profiles of single components was developed to solve the corresponding MINLPs, globally. In the multi-component setting, the mole fraction profiles of single components may not be monotonic, which is why the bound-...

In this paper numerical solutions of a two-phase natural convection dusty fluid flow are presented. The two-phase particulate suspension is investigated along a vertical cone by keeping variable viscosity and thermal conductivity of the carrier phase. Comprehensive flow formations of the gas and particle phases are given with the aim to predict the behavior of heat transport across the heated cone. The influence of i) air with particles, water with particles and oil with particles are shown o...

We consider the energetic description of a visco-plastic evolution and derive an existence result. The energies are convex, but not necessarily quadratic. Our model is a strain gradient model in which the curl of the plastic strain contributes to the energy. Our existence results are based on a time-discretization, the limit procedure relies on Helmholtz decompositions and compensated compactness.

Die vorliegende Dissertation gibt einen Überblick verschiedener Widerstände sektorenübergreifender Versorgung in der Bundesrepublik Deutschland. Tiefgreifende makroökonomische und sozioökonomische Auswirkungen – verursacht durch den demografischen Wandel – treffen vor allem ländliche Gebiete Deutschlands. Zukünftig kann daher der historisch ‚gewachsene‘ Status quo der Versorgung nicht mehr aufrechterhalten werden. Die Basis der Ausarbeitung sind Experteninterviews sowie aus den gewonnenen Erk...

We present a unique approach for integrating research in High Performance Computing (HPC) as well as photovoltaic (PV) solar farming and battery technologies into a container-based compute center designed for a maximum of energy efficiency, performance and extensibility/scalability. We use NVIDIA Jetson TK1 boards to build a considerably dimensioned cluster of 60 low-power GPUs, attach a 7:5 kWp solar farm and a 8 kWh Lithium-Ion battery power supply and integrate everything into a single-co...

Kleine GTPasen regulieren eine Vielzahl an hoch dynamischen Prozessen, welche von Signaltransduktion und Cytoskelettorganisation bis zum nuklearen und vesikulären Transport reichen. Sie erfüllen ihre regulatorische Rolle indem Sie als molekulare Schalter agieren, die zwischen einer aktiven, GTP-gebunden Form und einer inaktiven, GDP-gebundenen Form hin- und herwechseln. Der Wechsel zwischen der aktiven und der inaktiven Form geht mit einer Konformationsänderung der Proteinstruktur einher und ...

Embedded systems, such as mobile phones, integrate more and more features, e.g. multiple cameras, GPS sensors and many other sensors and actuators. These kind of embedded systems are dealing with increasing complexity due to demands on performance and constraints in energy consumption. The performance on such systems can be increased by executing application tasks in parallel. To achieve this, multiprocessor systems-on-chip (MPSoC) devices were introduced. On the other side, the energy consum...

In dieser Dissertation wird die erste Messung der b-tagging Effizienz eff(b) mit der pTrel-Methode am ATLAS Experiment unter Run 2 Bedingungen präsentiert. Die Messung wurde durchgeführt mit semileptonisch zerfallenden b-Hadronen mit einem Myon im Endzustand. Dies wurde erreicht durch Selektion von Myonen in einem Jet Kegel. Die pTrel-Variable is dabei sensitiv auf die Masse des schwach zerfallenden Teilchens und damit auf den Flavor des Jets. Dieser Zusammenhang lässt sich mit einem log-like...

Breast cancer is the most prevalent cancer that affects women all over the world. Early detection and treatment of breast cancer could decline the mortality rate. Some issues such as technical reasons, which related to imaging quality and human error, increase misdiagnosis of breast cancer by radiologists. Computer-aided detection systems (CADs) are developed to overcome these restrictions and have been studied in many imaging modalities for breast cancer detection in recent years. ...

DNA methylation at CpG rich regions often occurs at tumor suppressor gene promoters, resulting in reduced gene expression and final carcinogenesis. Hypermethylation of tumor suppressor genes, including DAPK-1 and RASSF-1α genes, have been found in patients with bladder carcinoma (BC) in some western countries. Reactive oxygen species (ROS) was reported to play a causative role in gene hypermethylation. In this study, we detected the methylation status and expression of DAPK1 and RAS...

Dibutyltin dichloride (DBTC) is an organotin compound used as model for acute and chronic pancreatitis. Oxidative stress is one of the mechanisms of propagation of acinar cell injury in acute pancreatitis. Selenium is an essential cofactor in the antioxidant glutathione peroxidase pathway. Selenium levels are described to be subnormal in patients with acute and chronic pancreatitis. The aim of our studies was to determine the prophylactic effect of Na-selenite [5 mg kg-1 body weight (b.w.) pe...