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The cyclic GMP-AMP synthase (cGAS) catalyzes the synthesis of the multifunctional second messenger, cGAMP, in metazoans. Although numerous cGAS homologues are predicted in protein databases, the catalytic activity towards cGAMP synthesis has been proven for only four of them. Therefore, we selected five novel and yet uncharacterized cGAS homologues, which cover a broad range in the field of vertebrates. Cell-free protein synthesis (CFPS) was used for a pre-screening to investigate if the cGAS...
Background:The raised demand of cannabis as a medicinal plant in recent years led to an increased interest in understanding the biosynthetic routes of cannabis metabolites. Since there is no established protocol to generate stable gene knockouts in cannabis, the use of a virus-induced gene silencing (VIGS) method, resulting in a gene knockdown, to study gene functions is desirable.Results:For this, a computational approach was employed to analyze the Cannabis sativa L. transcriptomic and geno...
The paper is concerned with an optimal control problem governed by the rate-independent system of quasi-static perfect elasto-plasticity. The objective is to optimize the stress field by controlling the displacement at prescribed parts of the boundary. The control thus enters the system in the Dirichlet boundary conditions. Therefore, the safe load condition is automatically fulfilled so that the system admits a solution, whose stress field is unique. This gives rise to a well defined control-to-...
Even though the turn to practice is widely accepted in the field of urban planning, the practices of planners are empirically largely unexplored. Looking at the daily routines and practices of urban planners thus allows a deeper insight into what planning is, and how planning practices are related to innovation and transformation. To do so, we start from the assumption that behaviour is a constellation of practices, including certain activities, a set of choices and actions, patterns of behav...
Analyzing and characterizing mechanical properties of polymers is a vast field of research. In this thesis, linear and nonlinear rheological investigations have been used to study the relaxation behavior of various glass-forming liquids. In simple (non-associating and non-polymeric) liquids, the microscopic flow behavior is associated to the mass transport which is defined by the dynamics of the molecules and therefore the structural relaxation. This is usually discussed in the literatur...
Focusing on real-time scheduling theory, the thesis demonstrates how essential realistic scheduling models and analyses are when guaranteeing timing correctness without over-provisioning the necessary system resources. It details potential pitfalls of the de facto standards for theoretical examination of scheduling algorithms and schedulability tests, namely resource augmentation bounds and utilization bounds, and proposes parametric augmentation functions to improve their meaningfulness. Con...
By means of electron beam powder bed fusion (E-PBF), highly complex lightweight structures can be manufactured within short process times. Due to the increasing complexity of producible components and the entangled interplay of damage mechanisms, common bulk material properties such as ultimate tensile or fatigue strength are not sufficient to guarantee safe and reliable use in demanding applications. Within this work, the damage tolerance of E-PBF-manufactured Ni-based alloy Inconel 718 (IN ...
Um Lebenschancen räumlich differenziert zu erfassen, stellt unser Beitrag in Anknüpfung an die Quartierseffekteforschung und den „capability approach“ einen Ansatz vor, der Lebenschancen als räumlich strukturierte Möglichkeiten und Wahlfreiheiten bei der Erfüllung von Bedürfnissen konzipiert. Individuelle Ressourcen entscheiden darüber, welche Möglichkeitsräume der Bedürfnisbefriedigung erschlossen werden können. Dies ist abhängig von der Lebenslage und verändert sich im Lebensverlauf, womit ...
In this thesis, a search for flavour-changing neutral currents in processes involving a singly produced top quark and a photon is presented. In this search, proton-proton collision data are used which were collected by the ATLAS experiment at the LHC and correspond to an integrated luminosity of 81 fb⁻¹. The top quark is assumed to decay into a b quark and a W boson, which is supposed to decay leptonically. Events are selected whose final state contains exactly one photon, one charged lepton,...
Imaging atmospheric Cherenkov telescopes (IACT) observe the sky in the highest energy ranges. From the remnants of cataclysmic supernovae to jets powered by supermassive blackholes in the center of distant galaxies, IACTs can capture the light emerging from the most extreme sources in the universe. With the recent advent of multi-messenger astronomy it has become critical for IACTs to publicly share their data and software. For the first time since the inception of IACT technology, in a...
Questionnaire for teachers in inclusive classrooms.
The involvement of protein kinase CK1δ in the pathogenesis of severe disorders such as Alzheimer’s disease, amyotrophic lateral sclerosis, familial advanced sleep phase syndrome, and cancer has dramatically increased interest in the development of effective small molecule inhibitors for both therapeutic application and basic research. Unfortunately, the design of CK1 isoform-specific compounds has proved to be highly complicated due to the existence of six evolutionarily conserved human CK1 m...
The long-term stability of pharmaceutical formulations of poorly-soluble drugs in polymers determines their bioavailability and therapeutic applicability. However, these formulations do not only often tend to crystallize during storage, but also tend to undergo unwanted amorphous-amorphous phase separations (APS). Whereas the crystallization behavior of APIs in polymers has been measured and modeled during the last years, the APS phenomenon is still poorly understood. In this study, the cryst...
Whenever a database is changed, any previously computed and stored result of a query evaluation on that database becomes invalid and needs to be updated. This update can in principle be conducted by re-evaluating the query from scratch. However, this approach might be too inefficient, especially for large databases. Instead, it is often advantageous to make use of the old query result and possibly further stored auxiliary information. A descriptive framework for studying this dynamic s...
Die Forderung nach einem inklusiven Schulsystem in Deutschland stellt auch die Frage nach Professionalitätsentwicklung von angehenden Lehrkräften neu. Eine Aufgabe von Lehrer*innenbildung ist, dafür zu sensibilisieren, dass Lehrer*innen eingebunden in Machtdynamiken sind und durch ihr bisweilen unbewusstes und unreflektiertes Handeln ausschließen und diskriminieren. Daher ist es von zentraler Bedeutung, bereits Studierenden des Lehramtes dazu anzuleiten, ihre eigene Rolle als markiert in sozi...
Die vorgestellte integrierte Fahrdynamikregelung bestimmt aus einer Bewegungsvorgabe auf Beschleunigungsebene, Messgrößen vom Fahrzeug und momentanen Umweltparametern Stellgrößen, die das Fahrzeug die Bewegungsanforderung möglichst exakt umsetzen lassen. Die Stellgrößen werden unter gleichzeitiger Berücksichtigung jeder Komponente der Bewegungsvorgabe und der Gesamtheit der verfügbaren Stellmöglichkeiten ermittelt. Verbleiben nach Umsetzen der Vorgabe Freiheitsgrade in den Stellgrößen, so wer...
Der neutrinolose doppelte Beta-Zerfall ist ein hypothetischer Kernzerfall dessen Nachweis grundlegende Fragen über bislang unbekannte Eigenschaften von Neutrinos liefern und auf Physik jenseits des Standard Modells der Teilchenphysik hindeuten würde. Das COBRA Experiment sucht nach diesem Zerfall mit Hilfe von CdZnTe Halbleiter-Detektoren. In dieser Arbeit wird ein wesentlich verbesserter Aufbau des Experiments, genannt Extended Demonstrator (XDEM), präsentiert. Um diesen zur verwirklich...