Optimal crossover designs in a model with self and mixed carryover effects with correlated errors

Abstract

We determine optimal crossover designs for the estimation of direct treatment effects in a model with mixed and self carryover effects. The model also assumes that the errors within each experimental unit are correlated following a stationary firrst-order autoregressive process. The paper considers situations where the number of periods for each experimental unit is at least four and the number of treatments is greater or equal to the number of periods.