Comparison of the Empirical Bayes and the Significance Analysis of Microarrays

Ickstadt, Katja; Krause, Andreas; Schwender, Holger

Comparison of the Empirical Bayes and the Significance Analysis of Microarrays

dc.contributor.author	Ickstadt, Katja	de
dc.contributor.author	Krause, Andreas	de
dc.contributor.author	Schwender, Holger	de
dc.date.accessioned	2004-12-06T18:41:54Z
dc.date.available	2004-12-06T18:41:54Z
dc.date.issued	2003	de
dc.description.abstract	Microarrays enable to measure the expression levels of tens of thousands of genes simultaneously. One important statistical question in such experiments is which of the several thousand genes are differentially expressed. Answering this question requires methods that can deal with multiple testing problems. One such approach is the control of the False Discovery Rate (FDR). Two recently developed methods for the identification of differentially expressed genes and the estimation of the FDR are the SAM (Significance Analysis of Microarrays) procedure and an empirical Bayes approach. In the two group case, both methods are based on a modified version of the standard t-statistic. However, it is also possible to use the Wilcoxon rank sum statistic. While there already exists a version of the empirical Bayes approach based on this rank statistic, we introduce in this paper a new version of SAM based on Wilcoxon rank sums. We furthermore compare these four procedures by applying them to simulated and real gene expression data.	en
dc.format.extent	497614 bytes
dc.format.mimetype	application/pdf
dc.identifier.uri	http://hdl.handle.net/2003/5012
dc.identifier.uri	http://dx.doi.org/10.17877/DE290R-15111
dc.language.iso	en	de
dc.publisher	Universitätsbibliothek Dortmund	de
dc.subject	identification of differentially expressed genes	en
dc.subject	gene expression	en
dc.subject	multiple testing	en
dc.subject	false discovery rate	en
dc.subject.ddc	310	de
dc.title	Comparison of the Empirical Bayes and the Significance Analysis of Microarrays	en
dc.type	Text	de
dc.type.publicationtype	report	en
dcterms.accessRights	open access

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