Preparation of micron and submicron particles via spray drying and electrostatic precipitation

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dc.contributor.authorJusten, Anna
dc.contributor.authorKurth, Christopher
dc.contributor.authorSchaldach, Gerhard
dc.contributor.authorThommes, Markus
dc.date.accessioned2023-10-18T13:44:23Z
dc.date.available2023-10-18T13:44:23Z
dc.date.issued2022-11-10
dc.description.abstractSmall particles are of great interest in a variety of applications. Spray drying is a common technique for particle synthesis, but it is limited with respect to sizes below 10 μm. Therefore, a new laboratory-scale spray dryer was designed to address this issue. A novel aerosol generator consisting of a piezo crystal in a swirl chamber was designed to obtain droplets in the low micrometer range. After drying and cooling, particles were deposited in a molten carrier, using melt electrostatic precipitation. The median particle size of three pharmaceutical drug substances was 2 μm. The size distribution was particularly narrow, with span values of about 1.1. Spray drying is a sufficient technique to produce small drug particles below 5 μm with ultrasonic atomization at high frequencies. Electrostatic precipitation in a molten carrier is a suitable method to capture these particles.en
dc.identifier.urihttp://hdl.handle.net/2003/42160
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-23993
dc.language.isoende
dc.relation.ispartofseriesChemical engineering & technology;46(2)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/de
dc.subjectElectrostatic precipitationen
dc.subjectMicronized particlesen
dc.subjectSpray dryingen
dc.subjectUltrasonic atomizationen
dc.subject.ddc660
dc.subject.rswkElektroentstaubungde
dc.subject.rswkTeilchengrößede
dc.subject.rswkZerstäubungstrocknungde
dc.subject.rswkZerstäubungde
dc.titlePreparation of micron and submicron particles via spray drying and electrostatic precipitationen
dc.typeTextde
dc.type.publicationtypeResearchArticlede
dcterms.accessRightsopen access
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationJusten, A., Kurth, C., Schaldach, G. and Thommes, M. (2023), Preparation of Micron and Submicron Particles via Spray Drying and Electrostatic Precipitation. Chem. Eng. Technol., 46: 343-349. https://doi.org/10.1002/ceat.202200357de
eldorado.secondarypublication.primaryidentifierDOI: https://doi.org/10.1002/ceat.202200357de

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