Adaptive Group Sequential Trials with the Standardized Mean Difference as Effect Size
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Date
2010-07-28
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Abstract
In a thorough and extensive simulation study, we investigate the practical properties of repeated
confidence intervals and point estimates for the standardized difference of normal means in
adaptive group sequential trials.
The theoretical foundations have been described in Hartung and Knapp (2009, 2010).
In the simulation study, we consider an adaptive three-stage Pocock (1977)-type design for planning
and showing noninferiority and an adaptive five-stage O'Brien-Fleming (1979)-type design for
planning and showing superiority.
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Keywords
Pocock-type design, O'Brien-Fleming-type design, noninferiority, superiority, repeated confidence intervals