Enzyme-induced mineralization of hydrogels with amorphous calcium carbonate for fast synthesis of ultrastiff, strong and tough organic–inorganic double networks

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dc.contributor.authorMilovanovic, Marko
dc.contributor.authorMihailowitsch, Lydia
dc.contributor.authorSanthirasegaran, Mathusiha
dc.contributor.authorBrandt, Volker
dc.contributor.authorTiller, Jörg C.
dc.date.accessioned2022-06-07T13:35:36Z
dc.date.available2022-06-07T13:35:36Z
dc.date.issued2021-06-23
dc.description.abstractHydrogels with good mechanical properties have great importance in biological and medical applications. Double-network (DN) hydrogels were found to be very tough materials. If one of the two network phases is an inorganic material, the DN hydrogels also become very stiff without losing their toughness. So far, the only example of such an organic–inorganic DN hydrogel is based on calcium phosphate, which takes about a week to be formed as an amorphous inorganic phase by enzyme-induced mineralization. An alternative organic–inorganic DN hydrogel, based on amorphous CaCO3, which can be formed as inorganic phase within hours, was designed in this study. The precipitation of CaCO3 within a hydrogel was induced by urease and a urea/CaCl2 calcification medium. The amorphous character of the CaCO3 was retained by using the previously reported crystallization inhibiting effects of N-(phosphonomethyl)glycine (PMGly). The connection between organic and inorganic phases via reversible bonds was realized by the introduction of ionic groups. The best results were obtained by copolymerization of acrylamide (AAm) and sodium acrylate (SA), which led to water-swollen organic–inorganic DN hydrogels with a high Young’s modulus (455 ± 80 MPa), remarkable tensile strength (3.4 ± 0.7 MPa) and fracture toughness (1.1 ± 0.2 kJ m−2).en
dc.identifier.urihttp://hdl.handle.net/2003/40938
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-22788
dc.language.isoende
dc.relation.ispartofseriesJournal of materials science;Bd 56. 2021, H. 27, S. 15299-15312
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.ddc660
dc.titleEnzyme-induced mineralization of hydrogels with amorphous calcium carbonate for fast synthesis of ultrastiff, strong and tough organic–inorganic double networksen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationJournal of materials science, Bd 56, H. 27, S. 15299-15312en
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1007/s10853-021-06204-6de

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