Nickel(BiPhePhos)-catalyzed hydrocyanation of styrene - highly increased catalytic activity by optimized operational procedures
Loading...
Date
2024-03-21
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Nitriles are versatile and highly desired chemical intermediates for a range of products.
Their economic large-scale production requires highly efficient and selective synthesis. The nickel-
catalyzed hydrocyanation of C=C double bonds provides such selective and 100% atom-economical
access to nitriles, but the catalysts hitherto lack activity and longevity. Yet, the literature focusing
on increased catalytic activity or optimized operational procedures is scarce, at the least. Here, we
present a thorough investigation and optimization of operational procedures using a commercially
available diphosphite ligand and styrene as a model substrate. This led us to achieve a TOF20 of more
than 300,000 h−1.
Description
Table of contents
Keywords
hydrocyanation, activity enhancement, BiPhePhos, homogeneous catalysis, nickel, hydrogen cyanide