Statistical analysis of Sequence-Structure Alignment Scores
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Date
2002
Journal Title
Journal ISSN
Volume Title
Publisher
Universitätsbibliothek Dortmund
Abstract
The structural analysis of proteins is fundamental to the analysis of protein functions. In this context, sequence-structure alignment methods are important among the different empirical methods. In order to assess the quality of sequence-structure alignments, a statistical method using a Bayesian approach proposed by Lathrop et al. (1998) will be presented. Finally, the results of a developed statistical analysis of scores of RDP(recursive dynamic programming)-sequence-structure alignments (Thiele et al., 1999) according to data of six proteins will be described.
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Table of contents
Keywords
sequence-structure-alignment, statistically significant scores, combined Bayesian approach and RDP-alignment