Optimal designs for the Michaelis Menten model with correlated observations

Simple item page
dc.contributor.authorDette, Holger
dc.contributor.authorKunert, Joachim
dc.date.accessioned2012-01-30T10:15:25Z
dc.date.available2012-01-30T10:15:25Z
dc.date.issued2012-01-30
dc.description.abstractIn this paper we investigate the problem of designing experiments for weighted least squares analysis in the Michaelis Menten model. We study the structure of exact D-optimal designs in a model with an autoregressive error structure. Explicit results for locally D-optimal are derived for the case where 2 observations can be taken per subject. Additionally standardized maximin D-optimal designs are obtained in this case. The results illustrate the enormous difficulties to find exact optimal designs explicitly for nonlinear regression models with correlated observations.en
dc.identifier.urihttp://hdl.handle.net/2003/29294
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-3372
dc.language.isoende
dc.relation.ispartofseriesDiscussion Paper / SFB 823;04/2012en
dc.subjectautoregressive errorsen
dc.subjectexact designsen
dc.subjectlocally D-optimal designsen
dc.subjectMichaelis Menten modelen
dc.subjectstandardized maximin optimal designen
dc.subject.ddc310
dc.subject.ddc330
dc.subject.ddc620
dc.titleOptimal designs for the Michaelis Menten model with correlated observationsen
dc.typeTextde
dc.type.publicationtypeworkingPaperde
dcterms.accessRightsopen access

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
DP_0412_SFB823_Dette_Kunert.pdf
Size:
298.48 KB
Format:
Adobe Portable Document Format
Description:
DNB
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.02 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Sonderforschungsbereich (SFB) 823