Effect of cholesterol on diffusion in surfactant bilayers

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dc.contributor.authorSuter, Dieter
dc.contributor.authorPieper, Thorsten
dc.contributor.authorMarkova, Svetlana
dc.contributor.authorKinjo, Masataka
dc.date.accessioned2008-02-12T16:35:17Z
dc.date.available2008-02-12T16:35:17Z
dc.date.issued2007-10-29
dc.description.abstractBiological membranes consist of lipid bilayers with liquid-ordered and liquid-disordered phases. It is believed that cholesterol controls the size of the microdomains in the liquid-ordered phase and thereby affects the mobility as well as the permeability of the membrane. We study this process in a model system consisting of the nonionic surfactant C12E5 and water in the lamellar phase. We measure the diffusion of fluorescent probe molecules (rhodamine B) by fluorescence correlation spectroscopy. For different surfactant to water ratios, we measure how the molecular mobility varies with the amount of cholesterol added. We find that a reduction of the diffusion coefficient is already detectable at a molar ratio of 8 mol % cholesterol.en
dc.identifier.citationT. Pieper, S. Markova, M. Kinjo, and D. Suter: Effect of cholesterol on diffusion in surfactant bilayers. In: J. Chem. Phys. 127, 165102 (2007).en
dc.identifier.doi10.1063/1.2794345
dc.identifier.urihttp://hdl.handle.net/2003/25027
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-3448
dc.identifier.urlhttp://link.aip.org/link/?JCPSA6/127/165102/1
dc.language.isoende
dc.publisherAmerican Institute of Physicsen
dc.rights©2007 American Institute of Physicsen
dc.subject.ddc530
dc.titleEffect of cholesterol on diffusion in surfactant bilayersen
dc.typeTextde
dc.type.publicationtypearticleen
dcterms.accessRightsrestricted
eldorado.identifier.urlhttp://e3.physik.tu-dortmund.de/~suter/eprints/MembraneDiffusion.pdf

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