Development of a new exercise-based approach to target Fatigue in Multiple Sclerosis
| dc.contributor.advisor | Zimmer, Philipp | |
| dc.contributor.author | Wolf, Florian Philipp | |
| dc.contributor.referee | Rauen, Katrin | |
| dc.date.accepted | 2024-12-11 | |
| dc.date.accessioned | 2025-02-07T09:59:16Z | |
| dc.date.available | 2025-02-07T09:59:16Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | In a joint decision between stakeholders from research (TU Dortmund University) and clinical practice (Neurological Rehabilitation Center Godeshoehe, Bonn), and considering evidence from the literature, fatigue was identified as a serious and common symptom in persons with multiple sclerosis (pwMS), where exercise might be applied as an efficacious intervention. Therefore, research efforts were directed at the development of an exercise-based fatigue intervention. In summary, publication 1 supported that aerobic training is not the most efficacious exercise type to reduce fatigue in pwMS. Publications 2-5 then developed a new group-based multimodal agility-based exercise training (MAT) framework centered on previously described working mechanisms regarding exercise and fatigue, and quantitatively and qualitatively evaluated the feasibility of conducting a randomized-controlled trial in a clinical inpatient rehabilitation setting to compare the new framework (MAT) with traditional strength and endurance training. Results showed that several changes need to be applied before the evaluation of the study protocol can be continued. Consequently, research can build on these early stage, but important results in the future. | en |
| dc.identifier.uri | http://hdl.handle.net/2003/43440 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-25271 | |
| dc.language.iso | en | |
| dc.subject | Fatigue | en |
| dc.subject | Multiple Sclerosis | en |
| dc.subject | Exercise | en |
| dc.subject | Rehabilitation | en |
| dc.subject | Agility | en |
| dc.subject.ddc | 796 | |
| dc.subject.rswk | Multiple Sklerose | de |
| dc.subject.rswk | Ermüdung | de |
| dc.subject.rswk | Bewegung | de |
| dc.subject.rswk | Rehabilitation | de |
| dc.title | Development of a new exercise-based approach to target Fatigue in Multiple Sclerosis | en |
| dc.type | Text | |
| dc.type.publicationtype | PhDThesis | |
| dcterms.accessRights | open access | |
| eldorado.secondarypublication | false |