Reaction optimization of a Suzuki‐Miyaura cross‐coupling using design of experiments

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dc.contributor.authorBobers, Jens
dc.contributor.authorHahn, Lisa Katharina
dc.contributor.authorAverbeck, Tobias
dc.contributor.authorBrunschweiger, Andreas
dc.contributor.authorKockmann, Norbert
dc.date.accessioned2024-03-01T12:27:55Z
dc.date.available2024-03-01T12:27:55Z
dc.date.issued2022-03-11
dc.description.abstractThe combination of lab automation and design of experiments for the execution of screening experiments increases productivity and reduces error-prone manual work. A self-developed software tool allows for creating fractional-factorial experimental design (FFED). Application of FFED on the screening of a Suzuki-Miyaura cross-coupling leads to a 93 % reduced design compared to full-factorial design. The resulting regression model qualitatively shows the positive effect of educt concentrations, time, and temperature and reveals the decrease in conversion at high base concentrations.en
dc.identifier.urihttp://hdl.handle.net/2003/42369
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-24206
dc.language.isoende
dc.relation.ispartofseriesChemie - Ingenieur - Technik;94(5)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/de
dc.subjectDesign of experimentsen
dc.subjectLab automationen
dc.subjectReaction optimizationen
dc.subjectSuzuki-Miyaura reactionen
dc.subject.ddc660
dc.subject.rswkVersuchsplanungde
dc.subject.rswkLabortechnikde
dc.subject.rswkAutomationde
dc.subject.rswkReaktionsoptimierungde
dc.subject.rswkSuzuki-Miyaura-Reaktionde
dc.titleReaction optimization of a Suzuki‐Miyaura cross‐coupling using design of experimentsen
dc.typeTextde
dc.type.publicationtypeArticlede
dcterms.accessRightsopen access
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationBobers, J., Hahn, L.K., Averbeck, T., Brunschweiger, A. and Kockmann, N. (2022), Reaction Optimization of a Suzuki-Miyaura Cross-Coupling Using Design of Experiments. Chemie Ingenieur Technik, 94: 780-785. https://doi.org/10.1002/cite.202100194en
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1002/cite.202100194de

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