Comparative life cycle assessment of chemical and biocatalytic 2’3’-cyclic GMP-AMP synthesis

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dc.contributor.authorBecker, Martin
dc.contributor.authorZiemińska-Stolarska, Aleksandra
dc.contributor.authorMarkowska, Dorota
dc.contributor.authorLütz, Stephan
dc.contributor.authorRosenthal, Katrin
dc.date.accessioned2023-10-18T14:08:11Z
dc.date.available2023-10-18T14:08:11Z
dc.date.issued2022-11-23
dc.description.abstractLife cycle assessments (LCAs) can provide insights into the environmental impact of production processes. In this study, a comparative LCA was performed for the synthesis of 2’3’-cyclic GMP-AMP (2’3’-cGAMP) in an early development stage. The cyclic dinucleotide (CDN) is of interest for pharmaceutical applications such as cancer immunotherapy. CDNs can be synthesized either by enzymes or chemical catalysis. It is not known which of the routes is more sustainable as both routes have their advantages and disadvantages, such as a poor yield for the chemical synthesis and low titers for the biocatalytic synthesis. The synthesis routes were compared for the production of 200 g 2’3’-cGAMP based on laboratory data to assess the environmental impacts. The biocatalytic synthesis turned out to be superior to the chemical synthesis in all considered categories by at least one magnitude, for example, a global warming potential of 3055.6 kg CO2 equiv. for the enzymatic route and 56454.0 kg CO2 equiv. for the chemical synthesis, which is 18 times higher. This study demonstrates the value of assessment at an early development stage, when the choice between different routes is still possible.en
dc.identifier.urihttp://hdl.handle.net/2003/42162
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-23995
dc.language.isoende
dc.relation.ispartofseriesChemSusChem;16(5)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/de
dc.subjectBiocatalysisen
dc.subjectCyclic dinucleotidesen
dc.subjectEnzyme catalysisen
dc.subjectLife cycle assessmenten
dc.subjectSustainable chemistryen
dc.subject.ddc660
dc.subject.rswkBiokatalysede
dc.subject.rswkDinucleotidede
dc.subject.rswkEnzymkatalysede
dc.subject.rswkUmweltbilanzde
dc.subject.rswkGrüne Chemiede
dc.titleComparative life cycle assessment of chemical and biocatalytic 2’3’-cyclic GMP-AMP synthesisen
dc.typeTextde
dc.type.publicationtypeResearchArticlede
dcterms.accessRightsopen access
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationBecker, M., Ziemińska-Stolarska, A., Markowska, D., Lütz, S., Rosenthal, K., ChemSusChem 2023, 16, e202201629.de
eldorado.secondarypublication.primaryidentifierDOI: https://doi.org/10.1002/cssc.202201629de

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