Imaging the uptake, distribution and metabolism of agrochemicals using MALDI mass spectrometry imaging

dc.contributor.advisorKusari, Souvik
dc.contributor.authorKubicki, Michael
dc.contributor.refereeRauh, Daniel
dc.date.accepted2022-07-06
dc.date.accessioned2022-07-28T12:05:54Z
dc.date.available2022-07-28T12:05:54Z
dc.date.issued2022
dc.description.abstractAgrochemicals such as fungicides, herbicides, or insecticides are widely used worldwide to control weeds, pests, and diseases to reduce the loss in crop production and increase yield and quality of crop products. Successful control and safe usage of these types of compounds depend on the compound reaching the target site within the crop plant. Therefore, monitoring agrochemical distribution within plant tissues delivers significant insights into agrochemicals adsorption, distribution, metabolism, and elimination (ADME). In the present dissertation, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) has been used to examine the uptake and distribution of a range of agrochemicals into a various number of crop plants and to complement their results with conventional methods such as autoradiography, liquid scintillation, and HPLC-MS. The uptake, distribution, metabolic behavior, and the nature of the residue of selected fungicides, herbicides and insecticides was investigated and delivered spatial information about the uptake and systemicity of the agrochemicals within the plants.en
dc.identifier.urihttp://hdl.handle.net/2003/41009
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-22858
dc.language.isoende
dc.subjectMALDI imagingen
dc.subjectEnvironmental scienceen
dc.subjectPlant protectionen
dc.subjectPesticideen
dc.subject.ddc540
dc.subject.rswkMatrix-unterstützte Laser-Desorptionde
dc.subject.rswkUmweltforschungde
dc.subject.rswkPestizidde
dc.titleImaging the uptake, distribution and metabolism of agrochemicals using MALDI mass spectrometry imagingen
dc.typeTextde
dc.type.publicationtypedoctoralThesisde
dcterms.accessRightsopen access
eldorado.secondarypublicationfalsede

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