Estimation of the Mean AUC of the Xenoestrogens Daidzein, Bisphenol A, and p-tert-Octylphenol
| dc.contributor.author | Degen, Gisela H. | de |
| dc.contributor.author | Selinski, Silvia | de |
| dc.date.accessioned | 2004-12-06T18:39:50Z | |
| dc.date.available | 2004-12-06T18:39:50Z | |
| dc.date.issued | 2003 | de |
| dc.description.abstract | Potentially adverse human and environmental effects due to hormone mimicry of environmental estrogens are a matter of current concern. Environmental estrogens belong to the so-called endocrine active compounds (EAC), which alter signalling processes of the endocrine system leading to a broad range of effects during foetal and postnatal development, puberty, adulthood, and aging. A number of synthetic chemicals as well as several plant-derived compounds, so-called phytoestrogens, are known to have weak estrogenic activity. The present study is part of the risk assessment of the weak environmental estrogens daidzein, p-tert-octylphenol, and bisphenol A. The isoflavone daidzein is an important phytoestrogen with respect to dietary exposure (soy beans and soy products). p-tert-Octylphenol and bisphenol A are industrial chemicals. The toxicokinetics and the bioavailability of these three substances in female DA/Han rats after oral and single intravenous application were investigated by the use of population models accounting for the differences in the individual metabolism. Furthermore, populations of pregnant and non-pregnant rats are compared. | en |
| dc.format.extent | 133073 bytes | |
| dc.format.extent | 450633 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/postscript | |
| dc.identifier.uri | http://hdl.handle.net/2003/4928 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-6944 | |
| dc.language.iso | en | de |
| dc.publisher | Universitätsbibliothek Dortmund | de |
| dc.subject | Bisphenol A | en |
| dc.subject | daidzein | en |
| dc.subject | p-tert-octylphenol | en |
| dc.subject | xenoestrogens | en |
| dc.subject | phytoestrogens | en |
| dc.subject | endocrine active compounds | en |
| dc.subject | bioavailability | en |
| dc.subject | AUC | en |
| dc.subject | population model | en |
| dc.subject | EM algorithm | en |
| dc.subject | Mann-Whitney-U-test | en |
| dc.subject.ddc | 310 | de |
| dc.title | Estimation of the Mean AUC of the Xenoestrogens Daidzein, Bisphenol A, and p-tert-Octylphenol | en |
| dc.type | Text | de |
| dc.type.publicationtype | report | en |
| dcterms.accessRights | open access |