Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method

Simple item page
dc.contributor.authorMattusch, Amelie M.
dc.contributor.authorSchaldach, Gerhard
dc.contributor.authorBartsch, Jens
dc.contributor.authorThommes, Markus
dc.date.accessioned2025-08-20T05:56:27Z
dc.date.available2025-08-20T05:56:27Z
dc.date.issued2024-03-19
dc.description.abstractFor a solid understanding of drug characteristics, in vitro measurement of the intrinsic dissolution rate is important. Hydrodynamics are often emphasized as the decisive parameter influencing the dissolution. In this study, experiments and computational fluid dynamic (CFD) simulations showed that the mixing behavior in the rotating disc apparatus causes an inhomogeneous flow field and a systematic error in the calculation of the intrinsic dissolution rate. This error is affected by both the experimental time and the velocity. Due to the rotational movement around the tablet center, commonly utilized in pharmacopeia methods, a broad variance is present with regard to the impact of fluid velocity on individual particles of the specimen surface. As this is significantly reduced in the case of uniform overflow, the flow channel is recommended for investigating the dissolution behavior. It is shown that rotating disc measurements can be compared with flow channel measurements after adjusting the measured data for the rotating disc based on a proposed, representative Reynolds number and a suggested apparatus-dependent correction factor. Additionally, modeling the apparatus-independent intrinsic dissolution rate for different temperatures in the rotating disc apparatus is possible using the adapted Levich’s equation.en
dc.identifier.urihttp://hdl.handle.net/2003/43843
dc.language.isoen
dc.relation.ispartofseriesPharmaceutical development and technology; 29(4)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectRotating discen
dc.subjectReynolds numberen
dc.subjectHydrodynamicsen
dc.subjectFlow channelen
dc.subjectIntrinsic dissolutionen
dc.subjectIDRen
dc.subjectCFDen
dc.subjectLevichen
dc.subjectPharmacopeiaen
dc.subjectApparatus- independenten
dc.subject.ddc660
dc.titleIntrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel methoden
dc.typeText
dc.type.publicationtypeResearchArticle
dcterms.accessRightsopen access
eldorado.doi.registerfalse
eldorado.secondarypublicationtrue
eldorado.secondarypublication.primarycitationMattusch, A. M., Schaldach, G., Bartsch, J., & Thommes, M. (2024). Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method. Pharmaceutical Development and Technology, 29(4), 281–290. https://doi.org/10.1080/10837450.2024.2329115
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1080/10837450.2024.2329115

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Intrinsic dissolution rate modeling for the pharmacopoeia apparatus rotating disk compared to flow channel method.pdf
Size:
1.87 MB
Format:
Adobe Portable Document Format
Description:
DNB
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.82 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Lehrstuhl Feststoffverfahrenstechnik