Efficient algorithms for calculating optimal designs in pharmacokinetics and dose finding studies
| dc.contributor.author | Dette, Holger | |
| dc.contributor.author | Holland-Letz, Tim | |
| dc.contributor.author | Renard, Didier | |
| dc.date.accessioned | 2010-10-27T11:40:22Z | |
| dc.date.available | 2010-10-27T11:40:22Z | |
| dc.date.issued | 2010-10-27 | |
| dc.description.abstract | Random effects models are widely used in population pharmacokinetics and dose finding studies. In such models the presence of correlated observations (due to shared random effects and possibly residual serial correlation) usually makes the explicit determination of optimal designs diffcult. In this paper we develop a class of multiplicative algorithms for the numerical calculation of optimal experimental designs in such situations. In particular we demonstrate its application in a concrete example of a cross-over dose finding trial. Additionally, we show that the methodology can be modified to determine optimal designs where there exist some requirements regarding the minimal number of treatments for several (in some cases all) experimental conditions. AMS Subject Classi cation: 62K05 | en |
| dc.identifier.uri | http://hdl.handle.net/2003/27439 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-15662 | |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Discussion Paper / SFB 823;41/2010 | |
| dc.subject | Correlated observation | en |
| dc.subject | Dose-finding study | en |
| dc.subject | Heteroscedastic regression | en |
| dc.subject | Locally optimal design | en |
| dc.subject | Multiplicative algorithm | en |
| dc.subject | Pharmacokinetic model | en |
| dc.subject | Random effect | en |
| dc.subject.ddc | 310 | |
| dc.subject.ddc | 330 | |
| dc.subject.ddc | 620 | |
| dc.title | Efficient algorithms for calculating optimal designs in pharmacokinetics and dose finding studies | en |
| dc.type | Text | de |
| dc.type.publicationtype | workingPaper | de |
| dcterms.accessRights | open access |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- DP_4110_SFB823_holland-letz_dette_renard.pdf
- Size:
- 359.26 KB
- Format:
- Adobe Portable Document Format
- Description:
- DNB
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1018 B
- Format:
- Item-specific license agreed upon to submission
- Description: