Ultrastrong poly(2‐oxazoline)/poly(acrylic acid) double‐network hydrogels with cartilage‐like mechanical properties

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dc.contributor.authorBenitez-Duif, Paola A.
dc.contributor.authorBreisch, Marina
dc.contributor.authorKurka, Daniel
dc.contributor.authorEdel, Karlina
dc.contributor.authorGökcay, Semra
dc.contributor.authorStangier, Dominic
dc.contributor.authorTillmann, Wolfgang
dc.contributor.authorHijazi, Montasser
dc.contributor.authorTiller, Jörg C.
dc.date.accessioned2024-02-08T10:03:37Z
dc.date.available2024-02-08T10:03:37Z
dc.date.issued2022-08-11
dc.description.abstractThe exceptional stiffness and toughness of double-network hydrogels (DNHs) offer the possibility to mimic even complex biomaterials, such as cartilage. The latter has a limited regenerative capacity and thus needs to be substituted with an artificial material. DNHs composed of cross-linked poly(2-oxazoline)s (POx) and poly(acrylic acid) (PAA) are synthesized by free radical polymerization in a two-step process. The resulting DNHs are stabilized by hydrogen bridges even at pH 7.4 (physiological PBS buffer) due to the pKa-shifting effect of POx on PAA. DNHs based on poly(2-methyl-2-oxazoline), which have a water content (WC) of around 66 wt% and are not cytotoxic, show biomechanical properties that match those of cartilage in terms of WC, stiffness, toughness, coefficient of friction, compression in body relevant stress conditions and viscoelastic behavior. This material also has high strength in PBS pH 7.4 and in egg white as synovial liquid substitute. In particular, a compression strength of up to 60 MPa makes this material superior.en
dc.identifier.urihttp://hdl.handle.net/2003/42316
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-24153
dc.language.isoende
dc.relation.ispartofseriesAdvanced functional materials;32(44)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/de
dc.subjectCartilageen
dc.subjectDouble-network hydrogelsen
dc.subjectPoly(2-oxazoline)en
dc.subjectPoly(acrylic acid)en
dc.subject.ddc660
dc.subject.rswkKnorpelde
dc.subject.rswkHydrogelde
dc.subject.rswkPolyoxazolinede
dc.subject.rswkPolyacrylsäurende
dc.subject.rswkRadikalische Polymerisationde
dc.titleUltrastrong poly(2‐oxazoline)/poly(acrylic acid) double‐network hydrogels with cartilage‐like mechanical propertiesen
dc.typeTextde
dc.type.publicationtypeResearchArticlede
dcterms.accessRightsopen access
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationP. A. Benitez-Duif, M. Breisch, D. Kurka, K. Edel, S. Gökcay, D. Stangier, W. Tillmann, M. Hijazi, J. C. Tiller, Ultrastrong Poly(2-Oxazoline)/Poly(Acrylic Acid) Double-Network Hydrogels with Cartilage-Like Mechanical Properties. Adv. Funct. Mater. 2022, 32, 2204837. https://doi.org/10.1002/adfm.202204837de
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1002/adfm.202204837de

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