Efficient synthesis of macromolecular DO3A@Gn derivatives for potential application in MRI diagnostics: from polymer conjugates to polymer nanoparticles

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dc.contributor.authorKampmann, Anne-Larissa
dc.contributor.authorHiller, Wolf
dc.contributor.authorWeberskirch, Ralf
dc.date.accessioned2024-01-11T10:02:22Z
dc.date.available2024-01-11T10:02:22Z
dc.date.issued2022-09-10
dc.description.abstractHerein, the synthesis of three different macromolecular DO3A@Gn conjugates based on poly(2-oxazoline)s is presented. Therefore, poly(2-methyl-2-oxazoline) is synthesized by a ring-opening, cationic polymerization and the polymerization is terminated with DO3A(tBu)3. The best results are obtained after 48 h at 120 °C with degree of termination of 86%. After deprotection of the DO3A ligand and complexation with Gn3+, relaxivity as measured with a magnetic field strength of 9.4 T (400 MHz) reveals values for r1 of up to 2.32 mm−1 s−1. The concept is extended to a block copolymer based on 2-heptyl-2-oxazoline and 2-methyl-2-oxazoline that is again terminated with DO3A(tBu)3 to form micelles with a size of 12.6 ± 0.7 nm after DO3A(tBu)3 termination and deprotection of the 1,4,7,10-tetraazacyclododecane-N,N,N,N-tetraacetic acid ligand. After complexation with Gn3+, relaxivity r1 is 10.1 mm−1 s−1 as determined from the slope of the plot of 1/T1 against the gadolinium(III) concentration at 9.4 T. Finally, crosslinked nanoparticles are prepared from amphiphilic macro-monomers that form micelles in water and are crosslinked throughout the core in the presence of azoisobutyronitrile (AIBN). The nanoparticle is 32.9 ± 7.8 nm in size after Gn3+ complexation and reveals a relaxivity r1 of 6.77 mm−1 s−1.en
dc.identifier.urihttp://hdl.handle.net/2003/42273
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-24110
dc.language.isoende
dc.relation.ispartofseriesMacromolecular chemistry and physics;224(1)
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/de
dc.subjectAmphiphilic poly(2-oxazoline)en
dc.subjectBifunctional macromonomers surfactantsen
dc.subjectMicroemulsion polymerizationen
dc.subjectPolymeric nanoparticlesen
dc.subject.ddc540
dc.titleEfficient synthesis of macromolecular DO3A@Gn derivatives for potential application in MRI diagnostics: from polymer conjugates to polymer nanoparticlesen
dc.typeTextde
dc.type.publicationtypeResearchArticlede
dcterms.accessRightsopen access
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationA.-L. Kampmann, W. Hiller, R. Weberskirch, Efficient Synthesis of Macromolecular DO3A@Gn Derivatives for Potential Application in MRI Diagnostics: From Polymer Conjugates to Polymer Nanoparticles. Macromol. Chem. Phys. 2023, 224, 2200211. https://doi.org/10.1002/macp.202200211de
eldorado.secondarypublication.primaryidentifierDOI https://doi.org/10.1002/macp.202200211de

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