Structural investigation of cholesterol homeostasis and bacterial toxins

Simple item page
dc.contributor.advisorRaunser, Stefan
dc.contributor.authorGünther, Patrick
dc.contributor.refereeSummerer, Daniel
dc.date.accepted2023-08-22
dc.date.accessioned2023-09-26T08:44:22Z
dc.date.available2023-09-26T08:44:22Z
dc.date.issued2023
dc.description.abstractMembrane proteins regulate a variety of processes that are critical for living organisms. They participate in cell-cell communication, catalyze reactions in or at the membrane, are involved in transmitting signals from the environment into the cell, and can transport molecules across membranes. Approximately 60% of all clinically approved drugs target membrane proteins, underscoring their importance. In order to understand the function of membrane proteins and to design more targeted drugs, determining their precise three-dimensional structures is required. In this PhD project, I aimed to structurally characterize two membrane protein complexes involved in the regulation of cholesterol homeostasis – the Scap-Insig and HMGCR-UBIAD1 complexes – and the type VI secretion system (T6SS) effector RhsA. My PhD work showcases that biochemical studies combined with structural determination by cryo-EM provides valuable insights into molecular processes that occur in or at the membrane and is of utmost pharmacological interest.en
dc.identifier.urihttp://hdl.handle.net/2003/42108
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-23941
dc.language.isoende
dc.subjectCryo-EMen
dc.subjectSingle particle analysisen
dc.subjectMembrane proteinsen
dc.subjectBacterial toxinsen
dc.subjectType VI secretion systemen
dc.subjectCholesterolen
dc.subject.ddc570
dc.subject.ddc540
dc.subject.rswkElektronenmikroskopiede
dc.subject.rswkMembranproteinede
dc.titleStructural investigation of cholesterol homeostasis and bacterial toxinsen
dc.typeTextde
dc.type.publicationtypePhDThesisde
dcterms.accessRightsopen access
eldorado.secondarypublicationfalsede

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Dissertation_Guenther.pdf
Size:
25.52 MB
Format:
Adobe Portable Document Format
Description:
DNB
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.85 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Chemische Biologie