Tropane alkaloids: chemistry, pharmacology, biosynthesis and production

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dc.contributor.authorKohnen-Johannsen, Kathrin Laura
dc.contributor.authorKayser, Oliver
dc.date.accessioned2019-05-02T12:10:06Z
dc.date.available2019-05-02T12:10:06Z
dc.date.issued2019-02-22
dc.description.abstractTropane alkaloids (TA) are valuable secondary plant metabolites which are mostly found in high concentrations in the Solanaceae and Erythroxylaceae families. The TAs, which are characterized by their unique bicyclic tropane ring system, can be divided into three major groups: hyoscyamine and scopolamine, cocaine and calystegines. Although all TAs have the same basic structure, they differ immensely in their biological, chemical and pharmacological properties. Scopolamine, also known as hyoscine, has the largest legitimate market as a pharmacological agent due to its treatment of nausea, vomiting, motion sickness, as well as smooth muscle spasms while cocaine is the 2nd most frequently consumed illicit drug globally. This review provides a comprehensive overview of TAs, highlighting their structural diversity, use in pharmaceutical therapy from both historical and modern perspectives, natural biosynthesis in planta and emerging production possibilities using tissue culture and microbial biosynthesis of these compounds.en
dc.identifier.urihttp://hdl.handle.net/2003/38035
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-20018
dc.language.isoende
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectTropane alkaloidsen
dc.subjectScopolamineen
dc.subjectCocaineen
dc.subjectCalystegineen
dc.subjectChemistryen
dc.subjectPharmacologyen
dc.subjectBiosynthesisen
dc.subjectBiotechnological productionen
dc.subject.ddc660
dc.subject.rswkAlkaloidede
dc.subject.rswkPharmaziede
dc.subject.rswkBiosynthesede
dc.titleTropane alkaloids: chemistry, pharmacology, biosynthesis and productionen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access
eldorado.openaire.projectidentifierinfo:eu-repo/grantAgreement/EC/FP7/613513/EU/From DISCOvery to products: A next generation pipeline for the sustainable generation of high-value plant products/DISCOde
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationKohnen-Johannsen, K.L.; Kayser, O. Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production. Molecules 2019, 24, 796de
eldorado.secondarypublication.primaryidentifierdoi:10.3390/molecules24040796de

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