Comprehensive study of the enhanced reactivity of turbo-Grignard reagents

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dc.contributor.authorHermann, Andreas
dc.contributor.authorSeymen, Rana
dc.contributor.authorBrieger, Lukas
dc.contributor.authorKleinheider, Johannes
dc.contributor.authorGrabe, Bastian
dc.contributor.authorHiller, Wolf
dc.contributor.authorStrohmann, Carsten
dc.date.accessioned2025-01-24T13:25:09Z
dc.date.available2025-01-24T13:25:09Z
dc.date.issued2023-03-27
dc.description.abstractSince its introduction in 2004, Knochel's so called Turbo-Grignard reagents revolutionized the usage of Grignard reagents. Through the simple addition of LiCl to a magnesium alkyl an outstanding increase in reactivity can be achieved. Though the exact composition of the reactive species remained mysterious, the reactive mixture itself is readily used not only in synthesis but also found its way into more distant fields like material science. To unravel this mystery, we combined single-crystal X-ray diffraction with in-solution NMR-spectroscopy and closed our investigations with quantum chemical calculations. Using such a variety of methods, we have gained insight into and an explanation for the extraordinary reactivity of this extremely convenient reagent by determining the structure of the first bimetallic reactive species [t-Bu2Mg ⋅ LiCl ⋅ 4 thf] with two tert-butyl anions at the magnesium center and incorporated lithium chloride.en
dc.identifier.urihttp://hdl.handle.net/2003/43384
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-25216
dc.language.isoen
dc.relation.ispartofseriesAngewandte Chemie / International edition; 62(25)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGrignard reactionen
dc.subjectMetal-halogen exchangeen
dc.subjectTurbo-Grignarden
dc.subjectX-ray diffractionen
dc.subject.ddc540
dc.titleComprehensive study of the enhanced reactivity of turbo-Grignard reagentsen
dc.typeText
dc.type.publicationtypeArticle
dcterms.accessRightsopen access
eldorado.secondarypublicationtrue
eldorado.secondarypublication.primarycitationA. Hermann, R. Seymen, L. Brieger, J. Kleinheider, B. Grabe, W. Hiller, C. Strohmann, Angew. Chem. Int. Ed. 2023, 62, e202302489.
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1002/anie.202302489

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