Towards reducing uncertainties in the applied effective dose for two specialized radiotherapy techniques

Heuchel, Lena

Towards reducing uncertainties in the applied effective dose for two specialized radiotherapy techniques

dc.contributor.advisor	Lühr, Armin
dc.contributor.author	Heuchel, Lena
dc.contributor.referee	Bäumer, Christian
dc.date.accepted	2024-04-17
dc.date.accessioned	2024-05-03T10:48:54Z
dc.date.available	2024-05-03T10:48:54Z
dc.date.issued	2023
dc.description.abstract	Radiotherapy is a high-precision treatment of malignant diseases. However, for some specialized techniques, e.g., total body irradiation (TBI) and proton therapy, considerable uncertainties remain regarding the applied effective dose. For some TBI techniques, no CT-based treatment planning is performed, therefore 3D dose distributions are unavailable. For proton therapy, the relative biological effectiveness (RBE) compared to standard photon irradiation is variable and subject to high uncertainties, particularly at the end of the proton range. Clinically, however, a constant RBE of 1.1 is assumed, since precise knowledge of the RBE distribution in patients, and therefore of the applied biological effective dose, is lacking. Two surveys among German and European clinics were performed to analyze the current clinical practice for TBI and proton therapy, respectively. These surveys showed that participating centers wish for new and improved guidelines for treatment planning, but important tools for analyzing the needed clinical data are missing. Therefore, these necessary tools were developed and tested by performing in silico patient irradiation studies. For TBI, a Monte Carlo-based simulation workflow was developed allowing for 3D dose calculations for non-CT-based TBI techniques. For proton therapy, a novel concept was introduced allowing for the reduction of dose components associated with high RBE uncertainties.	de
dc.identifier.uri	http://hdl.handle.net/2003/42461
dc.identifier.uri	http://dx.doi.org/10.17877/DE290R-24297
dc.language.iso	en	de
dc.subject	Total body irradiation	de
dc.subject	Proton therapy	de
dc.subject	Beam-zone methode	de
dc.subject	Relative biological effectiveness	de
dc.subject	Monte Carlo simulations	de
dc.subject.ddc	530
dc.subject.rswk	Ganzkörperbestrahlung	de
dc.subject.rswk	Protonentherapie	de
dc.subject.rswk	Monte-Carlo-Simulation	de
dc.title	Towards reducing uncertainties in the applied effective dose for two specialized radiotherapy techniques	de
dc.title.alternative	Total body irradiation and proton therapy	de
dc.type	Text	de
dc.type.publicationtype	PhDThesis	de
dcterms.accessRights	open access
eldorado.secondarypublication	false	de

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