The consequences of neglected confounding and interactions in mixed‐effects meta‐regression

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dc.contributor.authorKnop, Eric S.
dc.contributor.authorPauly, Markus
dc.contributor.authorFriede, Tim
dc.contributor.authorWelz, Thilo
dc.date.accessioned2025-01-07T11:22:24Z
dc.date.available2025-01-07T11:22:24Z
dc.date.issued2023-06-04
dc.description.abstractAnalysts seldom include interaction terms in their meta-regression model, which can introduce bias if an interaction is present. We illustrate this by reanalysing a meta-regression study in acute heart failure. Based on a total of 285 studies, the 1-year mortality rate related to acute heart failure is considered and the connection to the study-level covariates year of recruitment and average age of study participants are of interest. We show that neglecting a possibly confounding variable and an interaction term might lead to erroneous inference and conclusions. Based on our results and accompanying simulations, we recommend to include possible confounders and interaction terms, whenever they are plausible, in mixed-effects meta-regression models.en
dc.identifier.urihttp://hdl.handle.net/2003/43285
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-25117
dc.language.isoen
dc.relation.ispartofseriesResearch synthesis methods; 14(4)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectacute heart failureen
dc.subjectconfoundingen
dc.subjectinteractionsen
dc.subjectmeta-regressionen
dc.subject.ddc370
dc.titleThe consequences of neglected confounding and interactions in mixed‐effects meta‐regressionen
dc.title.alternativean illustrative exampleen
dc.typeText
dc.type.publicationtypeResearchArticle
dcterms.accessRightsopen access
eldorado.secondarypublicationtrue
eldorado.secondarypublication.primarycitationKnop ES, Pauly M, Friede T, Welz T. The consequences of neglected confounding and interactions in mixed-effects meta-regression: An illustrative example. Res Syn Meth. 2023; 14(4): 647-651. doi:10.1002/jrsm.1643
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1002/jrsm.1643

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