Assessment of randomization procedures in the presence of selection and chronological bias

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dc.contributor.advisorKunert, Joachim
dc.contributor.authorSchindler, David
dc.contributor.refereeMüller, Christine H.
dc.date.accepted2016-12-14
dc.date.accessioned2017-01-26T06:56:14Z
dc.date.available2017-01-26T06:56:14Z
dc.date.issued2016
dc.description.abstractEvery randomized clinical study needs a method of allocating treatments to patients to ensure the basis for a valid statistical inference. In the literature, the susceptibility of randomization procedures to both selection and chronological bias is already well studied. However, no optimality statement is given for the selection of a randomization procedure, when both types of bias are present simultaneously. Therefore, a linked assessment criterion for the selection of an appropriate randomization procedure is presented. The linked assessment criterion is based on desirability functions. For the calculation of the optimality score of a randomization procedure the importance of the investigated types of bias is considered. Several randomization procedures are compared for the sample sizes 12, 50 and 200. Finally, a recommendation for the choice of a randomization procedure is given in the presence of both selection and chronological bias.en
dc.identifier.urihttp://hdl.handle.net/2003/35768
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-17795
dc.language.isoende
dc.subjectChronological biasen
dc.subjectDesirability indexen
dc.subjectLinked assessment criterionen
dc.subjectRandomization in clinical trialsen
dc.subjectSelection biasen
dc.subject.ddc310
dc.subject.rswkKlinisches Experimentde
dc.subject.rswkBiasde
dc.subject.rswkRandomisierungde
dc.titleAssessment of randomization procedures in the presence of selection and chronological biasen
dc.typeTextde
dc.type.publicationtypedoctoralThesisen
dcterms.accessRightsopen access

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Lehrstuhl Mathematische Statistik und naturwissenschaftliche Anwendungen