Optimal Designs for Dose-Response Models with Restricted Design Spaces
| dc.contributor.author | Biedermann, Stefanie | de |
| dc.contributor.author | Dette, Holger | de |
| dc.contributor.author | Zhu, Wei | de |
| dc.date.accessioned | 2004-12-06T18:39:30Z | |
| dc.date.available | 2004-12-06T18:39:30Z | |
| dc.date.issued | 2004 | de |
| dc.description.abstract | In dose response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We present restricted and unrestricted interval locally optimal designs with respect to a very general class of optimality criteria for estimating the underlying dose response curve. The underlying curve belongs to a diversified set of link functions suitable for the dose response studies and having a common canonical form. These include the fundamental binary response models – the logit and the probit as well as the skewed versions of these models. The results are illustrated through the re-design of a dose ranging trial conducted at the Merck Research Laboratories (Zeng and Zhu, 1997). This work is a generalization of the results of Dai and Zhu (2002) in terms of the design interval, the underlying dose response curve and the optimality criterion. | en |
| dc.format.extent | 221220 bytes | |
| dc.format.extent | 458089 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/postscript | |
| dc.identifier.uri | http://hdl.handle.net/2003/4911 | |
| dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-5411 | |
| dc.language.iso | en | de |
| dc.publisher | Universitätsbibliothek Dortmund | de |
| dc.subject | binary response model | en |
| dc.subject | dose ranging | en |
| dc.subject | dose response | en |
| dc.subject | link function | en |
| dc.subject | general equivalence theorem | en |
| dc.subject | locally compound optimal design | en |
| dc.subject | information function | en |
| dc.subject | matrix mean | en |
| dc.subject.ddc | 310 | de |
| dc.title | Optimal Designs for Dose-Response Models with Restricted Design Spaces | en |
| dc.type | Text | de |
| dc.type.publicationtype | report | en |
| dcterms.accessRights | open access |