CycloSiFA: the next generation of silicon-based fluoride acceptors for positron emission tomography (PET)

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dc.contributor.authorMawick, Matthias
dc.contributor.authorJaworski, Carolin
dc.contributor.authorBittermann, Jens
dc.contributor.authorIovkova, Ljuba
dc.contributor.authorPu, Yinglan
dc.contributor.authorWängler, Carmen
dc.contributor.authorWängler, Björn
dc.contributor.authorJurkschat, Klaus
dc.contributor.authorKrause, Norbert
dc.contributor.authorSchirrmacher, Ralf
dc.date.accessioned2024-08-29T08:05:56Z
dc.date.available2024-08-29T08:05:56Z
dc.date.issued2023-10-18
dc.description.abstractThe ring-opening Si-fluorination of a variety of azasilole derivatives cyclo-1-(iPr2Si)−4-X−C6H3−2-CH2NR (4: R=2,6-iPr2C6H3, X=H; 4 a: R=2,4,6-Me3C6H2, X=H; 9: R=2,6-iPr2C6H3, X=tBuMe2SiO; 10: R=2,6-iPr2C6H3, X=OH; 13: R=2,6-iPr2C6H3, X=HCCCH2O; 22: R=2,6-iPr2C6H3, X=tBuMe2SiCH2O) with different 19F-fluoride sources was studied, optimized and the experience gained was used in a translational approach to create a straightforward 18F-labelling protocol for the azasilole derivatives [18F]6 and [18F]14. The latter constitutes a potential clickable CycloSiFA prosthetic group which might be used in PET tracer development using Cu-catalysed triazole formation. Based on our findings, CycloSiFA has the potential to become a new entry into non-canonical labelling methodologies for radioactive PET tracer development.en
dc.identifier.urihttp://hdl.handle.net/2003/42661
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-24497
dc.language.isoende
dc.relation.ispartofseriesAngewandte Chemie / International edition;62(50)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/de
dc.subjectAzasiloleen
dc.subjectFluorineen
dc.subjectPositron emission tomographyen
dc.subjectRing openingen
dc.subjectSiliconen
dc.subject.ddc540
dc.titleCycloSiFA: the next generation of silicon-based fluoride acceptors for positron emission tomography (PET)en
dc.typeTextde
dc.type.publicationtypeResearchArticlede
dcterms.accessRightsopen access
eldorado.secondarypublicationtruede
eldorado.secondarypublication.primarycitationM. Mawick, C. Jaworski, J. Bittermann, L. Iovkova, Y. Pu, C. Wängler, B. Wängler, K. Jurkschat, N. Krause, R. Schirrmacher, Angew. Chem. Int. Ed. 2023, 62, e202309002.de
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1002/anie.202309002de

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