Authors: | Bülow, Leif Isarankura-Na-Ayudhya, Chartchalerm Nantasenamat, Chanin Prachayasittikul, Virapong Ye, Lei |
Title: | In silico design for synthesis of molecularly imprinted microspheres specific towards bisphenol A by precipitation polymerization |
Language (ISO): | en |
Abstract: | Bisphenol A (BPA), a ubiquitous chemical used in industries, has attracted great attention due to its widespread leakage to the environment and foodstuff. This has spurred great interest in the preparation of synthetic polymers capable of selectively sequestering BPA. In this study, theoretical calculation was utilized to confirm the selection of suitable functional monomer capable of strong interaction with BPA. It was found that 4-vinylpyridine was the optimal functional monomer as demonstrated in the literature. A series of molecularly imprinted polymers (MIPs) were prepared by varying the functional monomer, cross-linker, and porogen. After template removal, rebinding with the original template molecule was carried out in acetonitrile, acetonitrile/water (50/50 - 20/80, v/v). 4-vinylpyridine co-polymerized with ethylene glycol dimethacrylate (4VPY-co-EDMA) and 4-vinylpyridine co-polymerized with trimethylolpropane trimethacrylate (4VPY-co-TRIM) were found to exhibit good binding performance towards bisphenol A in acetonitrile. However, only 4VPY-co-EDMA was able to maintain its imprinting effect in acetonitrile/water (50/50 v/v) whereas 4VPY-co-TRIM totally lost its imprinting effect. |
Subject Headings: | Bisphenol A estrogen disruptor microspheres molecular imprinting precipitation polymerization |
URI: | http://hdl.handle.net/2003/25668 http://dx.doi.org/10.17877/DE290R-8284 |
Issue Date: | 2006-09-26 |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Prachayasittikul16-06proofrev-update23092006.pdf | DNB | 1.55 MB | Adobe PDF | View/Open |
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