Aims and ScopeThe journal publishes original research reports, authoritative reviews and case reports of experimental and clinical sciences.
The EXCLI Journal is particularly keen to keep a broad view of science and technology, and therefore welcomes papers which bridge disciplines and may not suit the narrow specialism of other journals. Although the general emphasis is on biological sciences, physical and chemical aspects are published often.
Note: EXCLI Journal is entirely independent of the University of Dortmund and the Leibniz Research Centre for Working Environment and Human Factors, Dortmund. Views expressed are those of the editors of EXCLI Journal or its authors.
- Open access to full text articles as the journal is managed by the Leibniz Research Centre for Working Environment and Human Factors with no commercial interest
- Publication is free of costs for scientists
- Color pictures are also published free of costs
- Online submission and reviewing process
- Publication is rapid: EXCLI J guarantees a decision by two referees within 20 days after the manuscript is received.
- Fast track system: Many authors may feel their data should be published even faster. EXCLI J will agree to a manuscript entering fast-track when this is requested by the authors. In this case EXCLI J is prepared to give a decision within 7 days. However, the rate of rejections is higher for the fast track.
- First submissions of manuscripts may be done in any format. For instance, it is not necessary to format references in the style of EXCLI J. As soon as a manuscript is accepted the authors may format their article in the style of EXCLI J. We guarantee publication within 7 days as soon as we receive an accepted, correctly formatted manuscript.
- Although the majority of our articles does not exceed 10 pages there is no limitation of space. Long articles and extensive reviews are also welcome. Also extensive descriptions of Materials and Methods that facilitate reproduction of experiments as well as additional materials (films, simulations, original data sets) may be published by EXCLI J.
- EXCLI J is a new journal. Nevertheless, the average citation rate of an article published since our foundation in December 2002 and February 2005 is 2.4 citations per article considering exclusively citations indexed by ISI Web of Science.
- Areas of interest of EXCLI J include: Biochemistry, Biomedical Research, Biology, Cell Biology, Clinical Studies, Developmental Biology, Genetics, Immunology, Legal Medicine, Molecular Biology, Neurobiology, Oncology, Pharmacology, Plant Biology, Proteomics, Systems Biology, Toxicology.
Downregulation of miR-195 in colorectal cancer tissues has been reported in several studies. We investigated the impact exogenous induction of mature miR-195-5p on some malignant features of human colorectal cancer cells. Caco-2 and SW480 human colon cancer cell lines were transfected with a synthetic miR-195-5p mimic. Exogenous induction of miR-195-5p suppressed multiple mediators of invasion and angiogenesis in colorectal cancer cells and increased the apoptotic cell population in both cell...
The purpose of this study was to clarify the mechanisms of the protective effects of low-dose sodium nitrite (SN) on oxygen and glucose deprivation (OGD)-induced endoplasmic reticulum (ER) stress in PC12 cells. The PC12 cells were exposed to 4 h of OGD and treated with 100 μmol SN. The expression and activity of ER stress markers, including PKR-like endoplasmic reticulum kinase (PERK), transcription factor 6 (ATF6), CCAAT/enhancer binding protein homologous protein (CHOP), as well as caspase-...
Sirtuin 1 (SIRT1) enzyme regulates major cell activities, and its activation offers lucrative therapeutic potentials for aging diseases including Alzheimer’s disease (AD). Regarding the global aging society, continual attention has been given to various chemical scaffolds as a source for the discovery of novel SIRT1 activators since the discovery of the pioneer activator, resveratrol. Understanding structure-activity relationship (SAR) is essential for screening, designing as well as impr...
Heat shock protein 90 (HSP90), an ATP-dependent molecular chaperone required for the stability and function of numerous oncogenic signaling, is one of the hallmarks of cancer. Recent years, the studies showed that HSP90 plays a pivotal role in epigenetic pathways. Epigenetic regulation plays an important role in the etiology of bladder cancer. The aim of the present study was to investigate the effect of HSP90 proteins on DNA methylation and the levels of inactivated histone methylation m...
Prostate cancer (PCa) is one of the leading causes of cancer-related death in men. Blocking androgen receptor (AR) signaling is an effective treatment strategy for the treatment of advanced metastatic disease of PCa in men. However, the method of blocking AR signaling is not suitable for castration-resistant prostate cancer (CRPC), and the treatment of CRPC is still clinically difficult. It has recently been reported that MCT4 is a plasma membrane transporter that mediates the secretion o...
The traditional uses of Portulaca oleracea L. (PO) with anti-inflammatory and anti-cancer activity as well as antioxidants properties were expressed previously. Glioma is considered the most common primary brain tumor and its malignant form is the most lethal adult brain tumor, that glioblastoma covers about 50 % of glioma tumors. The present study was aimed to evaluate the cytotoxicity and apoptogenic effects of the hydro-ethanolic extract of PO on human glioblastoma cancer cell line (U-...
Piperine (1-piperoylpeperdine), a nitrogenous pungent substance, is present in the fruits of black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.). It possesses several pharmacological properties and has been extensively explored for its anti-cancerous activities. The mechanism underlying its anti-cancer potential in human cervical adenocarcinoma (HeLa) cells is not well interpreted. The anti-proliferative effect and the mode of action of piperine were investigated through so...
This study investigated the ability of intra-subventricular zone (SVZ) administration of cerebral dopamine neurotrophic factor (CDNF) on neural progenitor cells (NPCs) attraction from the SVZ toward the 6-hydroxydopamine (6-OHDA)-lesioned striatum and improvement of motor dysfunctions in Parkinsonian rats. Male Wistar rats were assigned to four groups of the sham model (Sham), 6-OHDA-lesioned (OH), 6-OHDA-lesioned plus CDNF vehicle (OH+Vehicle), and 6-OHDA-lesioned plus CDNF (OH+CDNF). The an...
The therapeutic potential of Baccharis anomala DC. extracts was evaluated through its cytotoxic and antiproliferative effect and their phenotypic reversion property in activated hepatic stellate cells (HSCs). Baccharis anomala is distributed in Brazil (southeastern and south regions) and used for diuretic effect in folk medicine. Four fractions were obtained from the fractionation of the methanolic extract. Fractions III and IV decreased cell proliferation without increasing cell necrosis mar...
Prostate cancer is a complex, progressive, bone-tropic disease, which is usually associated with skeletal issues, poor mobility and a fatal outcome when it reaches the metastatic phase. Soy isoflavones, steroid-like compounds from soy-based food/dietary supplements, have been found to decrease the risk of prostate cancer in frequent consumers. Herein, we present a systematization of the data on soy isoflavone effects at different stages of metastatic prostate cancer progression, with a parti...
Glycogen storage disease type I (GSD I) is a relatively rare metabolic disease with variable clinical intensity. It is caused by deficient activity of the glucose 6-phosphatase enzyme (GSD Ia) or a deficiency in the microsomal transport proteins for glucose 6-phosphate (GSD Ib). We searched the most recent English literature (1997-2017) regarding any article with the key word of “glycogen storage disease type I” in PubMed, Science Direct, Scopus, EMBASE, and Google Scholar. We will present al...
Multidrug resistant (MDR) Pseudomonas aeruginosa having strong biofilm potential and virulence factors are a serious threat for hospitalized patients having compromised immunity. In this study, 34 P. aeruginosa isolates of human origin (17 MDR and 17 non-MDR clinical isolates) were checked for biofilm formation potential in enriched and minimal media. The biofilms were detected using crystal violet method and a modified software package of the automated VideoScan screening method. Cytotox...
Repeated administration of hepatotoxicants is usually accompanied by liver fibrosis. However, the difference in response as a result of repeated exposures of acetaminophen (APAP) compared to a single dose is not well-studied. Therefore, in the current study, the liver response after a second dose of APAP was investigated. Adult fasted Balb/C mice were exposed to two toxic doses of 300 mg/kg APAP, which were administered 72 h apart from each other. Subsequently, blood and liver from the tr...
Pharmaceutical effluents contain toxic xenobiotics capable of contaminating aquatic environments. Untreated effluents are illegally discharged into aquatic environment in most developing countries. Pharmaceutical effluent induced alterations in biomarkers of genetic and systemic damage on rodents. However, information is relatively scarce on the possible cytogenotoxicity and systemic toxicity of this effluent on aquatic ertebrates. The study herein assessed the cytogenotoxic, hematological an...
- J. G. Hengstler
Leibniz Research Centre for Working Environment and Human Factors
- B. C. Behera, Pune, India
- T. Chen, Stanford, CA/USA
- E. Corsini, Milan, Italy
- P. Diel, Cologne, Germany
- C. Esser, Duesseldorf, Germany
- P. B. Farmer, Leicester/UK
- S. Hammad, South Valley/Egypt
- P. Jennings, Innsbruck, Austria
- M. Lotti, Bonn, Germany / Padova, Italy
- P. Micke, Uppsala, Sweden
- A. N. Misra, Ranchi, Jharkhand State, India
- B. Ponugoti, Pennsylvania, PA/USA
- C. Pope, Stillwater, OK/USA
- K. Renganathan, Johnstown, PA/USA
- S. D. Ray, Fort Wayne, IN/USA
- M. Schwarz, Tuebingen, Germany
- J. Timmer, Freiburg, Germany
- H. van Steeg, Bilthoven, The Netherlands
- A. Winterpacht, Erlangen, Germany
- Y. Zhou, New Haven, CT/USA
Address & Contact:Susanne Lindemann
Managing editor/EXCLI Journal
Leibniz Research Centre for Working Environment and Human Factors
Fon +49 231 1084 251