Aims and ScopeThe journal publishes original research reports, authoritative reviews and case reports of experimental and clinical sciences.
The EXCLI Journal is particularly keen to keep a broad view of science and technology, and therefore welcomes papers which bridge disciplines and may not suit the narrow specialism of other journals. Although the general emphasis is on biological sciences, physical and chemical aspects are published often.
Note: EXCLI Journal is entirely independent of the University of Dortmund and the Leibniz Research Centre for Working Environment and Human Factors, Dortmund. Views expressed are those of the editors of EXCLI Journal or its authors.
- Open access to full text articles as the journal is managed by the Leibniz Research Centre for Working Environment and Human Factors with no commercial interest
- Publication is free of costs for scientists
- Color pictures are also published free of costs
- Online submission and reviewing process
- Publication is rapid: EXCLI J guarantees a decision by two referees within 20 days after the manuscript is received.
- Fast track system: Many authors may feel their data should be published even faster. EXCLI J will agree to a manuscript entering fast-track when this is requested by the authors. In this case EXCLI J is prepared to give a decision within 7 days. However, the rate of rejections is higher for the fast track.
- First submissions of manuscripts may be done in any format. For instance, it is not necessary to format references in the style of EXCLI J. As soon as a manuscript is accepted the authors may format their article in the style of EXCLI J. We guarantee publication within 7 days as soon as we receive an accepted, correctly formatted manuscript.
- Although the majority of our articles does not exceed 10 pages there is no limitation of space. Long articles and extensive reviews are also welcome. Also extensive descriptions of Materials and Methods that facilitate reproduction of experiments as well as additional materials (films, simulations, original data sets) may be published by EXCLI J.
- EXCLI J is a new journal. Nevertheless, the average citation rate of an article published since our foundation in December 2002 and February 2005 is 2.4 citations per article considering exclusively citations indexed by ISI Web of Science.
- Areas of interest of EXCLI J include: Biochemistry, Biomedical Research, Biology, Cell Biology, Clinical Studies, Developmental Biology, Genetics, Immunology, Legal Medicine, Molecular Biology, Neurobiology, Oncology, Pharmacology, Plant Biology, Proteomics, Systems Biology, Toxicology.
Since ancient times, natural products from plants, animals, microbial and marine sources have been exploited for treatment of several diseases. The knowledge of our ancestors is the base of modern drug discovery process. However, due to the presence of extensive biodiversity in natural sources, the percentage of secondary metabolites screened for bioactivity is low. This review aims to provide a brief overview of historically significant natural therapeutic agents along with some current ...
Lead (Pb) intoxication remains a major health hazard causing various deleterious effects especially on renal and hematologic system. The current study elucidated the potential protective effect of JRVO against nephrotoxicity induced by lead. Male rats were randomly divided into three groups: group one (control) received ad libitum distilled water and 1 mL of saline solution (0.9 %) given by intra-peritoneal (i.p) injection, group two (Pb) was kept on tap distilled water and animals were i...
Survivin is a member of the apoptosis inhibitor protein family and its polymorphisms may lead to susceptibility to cancer. The aim of this study was to investigate the possible association of c.-31G>C (rs9904341), c.454G>A (rs2071214), c.*148T>C (rs2239680) and c.*571T>C (rs1042489) polymorphisms of survivin gene with prostate cancer risk and provide some justification using in silico analysis. The 157 men with prostate cancer and 145 healthy controls were included in a case-control study...
This study aimed to investigate the influence of lifestyle behaviors on the vitamin C levels in the circulating blood of the Thai population in Bangkok Metropolitan. The participants (n=250) included community workers (i.e., construction and business office workers) from the Bangkok Metropolitan, and the participants were placed in various behavior and lifestyle groups (Group I: reference; Group II: alcohol drinkers; Group III: outdoor workers; Group IV: smokers; and Group V: combined). T...
An enzyme-coupled colorimetric assay for quantification of urinary sarcosine was developed. The proposed method is a specific reaction based on hydrogen peroxide (H2O2) formation via sarcosine oxidase (SOX). The liberated H2O2 reacts with Amplex Red in the presence of horseradish peroxidase (HRP) to produce the redfluorescent oxidation product, resorufin, which can be measured spectrophotometrically (OD570). The method was performed in the 96-well microtiter plate. Reaction conditions, su...
Background: Delayed wound healing is a diverse, multifactorial, complex and inter-related complication of diabetes resulting in significant clinical morbidity. Hesperidin possesses potent antidiabetic and wound healing activity. Aim: To evaluate the potential of hesperidin against experimentally induced diabetes foot ulcers. Methods: Diabetes was induced experimentally by streptozotocin (STZ, 55 mg/kg, i.p.) in Sprague Dawley rats (180-220 g) and wounds were created on the dorsal surface of t...
Activation of the Wnt signaling in some types of cancer and its relation with chemotherapy resistance is a very interesting issue that has been emphasized in recent years. Although, it is known that increase in the activity of β-catenin is important in blast transformation and drug resistance, the underlying mechanisms are still unclear. In this study, changes in the expression levels of 186 genes that are thought to be important in drug resistance and Wnt signaling pathways were determin...
Diabetes is associated with numerous metabolic and vascular risk factors that contribute to a high rate of microvascular and macro-vascular disorders leading to mortality and morbidity from diabetic complications. In this case, the major cause of death in overall diabetic patients results from diabetic nephropathy (DN) or renal failure. The risk factors and mechanisms that correspond to the development of DN are not fully understood and so far, no specific and sufficient diagnostic biomar...
Measures of human physical capacity are required in ergonomic work design. To avoid biomechanical low-back overload, criteria are needed to differentiate load and overload. With respect to the evaluation of manual materials handling and similar physical exposures regarding potential overload, the compression component of the forces transferred via lumbar discs or vertebrae are compared with the ultimate compressive strength of lumbarspine segments in a common biomechanical approach. As me...
In this study, for the first time, an electro-driven microextraction method named electromembrane extraction combined with a simple high performance liquid chromatography and ultraviolet detection was developed and validated for the quantitation of zolpidem in biological samples. Parameters influencing electromembrane extraction were evaluated and optimized. The membrane consisted of 2-ethylhexanol immobilized in the pores of a hollow fiber. As a driving force, a 150 V electric field was ...
Mixed-ligand metal (II) (M=Cu, Fe, Co and Zn) complexes containing 2-butanone thiosemicarbazone and 1, 10-phenanthroline have been synthesized and characterized by melting point, FT-IR, 1H-NMR, UVspectrophotometry and molar conductance measurements. All the complexes were soluble in DMSO and DMF. They were thermally stable with high melting points. The computational studies of the complexes were also performed to assess toxicity potential, bioactivity score prediction and drug likeliness asse...
NOD-like receptor 3 (NLRP3) plays critical roles in the initiation of inflammasome-mediated inflammation in microglia, thus becomes an important therapeutic target of Alzheimer’s disease (AD). Dexmedetomidine (Dex), a new type of clinical anesthetic agent, shows anti-inflammatory properties and inhibits postoperative cognitive dysfunction in AD patients. The present study was aimed to investigate effect of Dex on NLRP3 activity in activated microglia and reveal the underlying mechanisms. ...
Rheumatoid arthritis (RA) is a systemic autoimmune disease whose major characteristics persistent joint inflammation that results in joint destruction and failure of the function. Collagen-induced arthritis (CIA) rat is an autoimmune disease model and in many ways shares features with RA. The CIA is associated with systemic manifestations, including alterations in the metabolism. Nuclear magnetic resonance (NMR) spectroscopy-based metabolomics has been successfully applied to the perchlor...
The pathological phenomenon of somatopause, noticeable in hypogonadal ageing subjects, is based on the growth hormone (GH) production and secretion decrease along with the fall in GH binding protein and insulin-like growth factor 1 (IGF-1) levels, causing different musculoskeletal, metabolic and mental issues. From the perspective of safety and efficacy, GH treatment is considered to be highly controversial, while some other therapeutic approaches (application of IGF-1, GH secretagogues, gona...
Colorectal cancer (CRC) is a heterogeneous disease that is caused by the interaction of genetic and environmental factors. Although it is one of the most common cancers worldwide, CRC would be one of the most curable cancers if it is detected in the early stages. Molecular changes that occur in colorectal cancer may be categorized into three main groups: 1) Chromosomal Instability (CIN), 2) Microsatellite Instability (MSI), and 3) CpG Island Methylator phenotype (CIMP). Microsatellites, also ...
Metabolic syndrome (MS) is a condition associated with metabolic abnormalities that are characterized by central obesity (e.g. waist circumference or body mass index), hypertension (e.g. systolic or diastolic blood pressure), hyperglycemia (e.g. fasting plasma glucose) and dyslipidemia (e.g. triglyceride and high-density lipoprotein cholesterol). It is also associated with the development of diabetes mellitus (DM) type 2 and cardiovascular disease (CVD). Therefore, the rapid identification of...
- J. G. Hengstler
Leibniz Research Centre for Working Environment and Human Factors
- B. C. Behera, Pune, India
- T. Chen, Stanford, CA/USA
- E. Corsini, Milan, Italy
- P. Diel, Cologne, Germany
- C. Esser, Duesseldorf, Germany
- P. B. Farmer, Leicester/UK
- S. Hammad, South Valley/Egypt
- P. Jennings, Innsbruck, Austria
- M. Lotti, Bonn, Germany / Padova, Italy
- P. Micke, Uppsala, Sweden
- A. N. Misra, Ranchi, Jharkhand State, India
- B. Ponugoti, Pennsylvania, PA/USA
- C. Pope, Stillwater, OK/USA
- K. Renganathan, Johnstown, PA/USA
- S. D. Ray, Fort Wayne, IN/USA
- M. Schwarz, Tuebingen, Germany
- J. Timmer, Freiburg, Germany
- H. van Steeg, Bilthoven, The Netherlands
- A. Winterpacht, Erlangen, Germany
- Y. Zhou, New Haven, CT/USA
Address & Contact:Susanne Lindemann
Managing editor/EXCLI Journal
Leibniz Research Centre for Working Environment and Human Factors
Fon +49 231 1084 251