We report the case of a 50-year old male patient presenting with a combination of chondrocalcinosis and osteoporosis related to a renal tubular disorder. Laboratory studies revealed hypokalemia, hypomagnesemia, hypocalcemia with renal wastage and metabolic alkalosis, compatible with a renal tubular transport disorder with similarities to Bartter's and Gitelman's syndrome. Calcifications of the menisci and cartilage on X-rays of knee joints suggested chondrocalcinosis, which has been associate...
Bradykinin is a key mediator of pain and inflammation. Although radiotherapy has proven to be beneficial in the treatment of inflammatory disorders, the effect of irradiation on the bradykinin pathway in human cells has not been evaluated yet. Therefore, the aim of the study was to establish a human cell culture system and to analyze bradykinin B2 receptor expression in response to different doses of gamma-ray exposure. Cultured human foreskin fibroblasts (HF15) were irradiated with 0.5 Gy, 2...
Tumor incidence for renal cell carcinoma is two-fold higher in males than in females. Members of the protein kinase C (PKC) gene family have been shown to be relevant for carcinogenesis. However, little is known about a possible gender specific role of PKC in renal cell carcinoma (RCC). In this study, we quantified expression of eleven PKC-isoforms in clear cell RCCs (ccRCC) and in the corresponding normal renal tissue. A possible association of PKC-isoforms with gender of the patients was ex...
The human microsomal epoxide hydrolase, a single enzyme, has to detoxify a broad range of structurally diverse, potentially genotoxic epoxides that are formed in the course of xenobiotic metabolism. The enzyme has developed a unique strategy to combine a broad substrate specificity with a high detoxification efficacy, by immediately trapping the reactive compounds as covalent intermediates and by being expressed at high levels for high trapping capacity. Computer simulation and experimental d...
- M.-A. von Mach
- J. G. Hengstler
Leibniz Research Centre for Working Environment and Human Factors
- L. S. Weilemann, Mainz, Germany
- I. Ishibashi, Tokyo, Japan
- P. Micke, Uppsala, Sweden
- J. Timmer, Freiburg, Germany
- A. Winterpacht, Erlangen, Germany
- B. C. Behera, Pune, India
Address & Contact:EXCLI
Mrs. S. Lindemann
Institute for Occupational Physiology
at the University of Dortmund
Leibniz Research Centre
for Working Environment and Human Factors