MiRNA-associated genetic variants occurring in regulatory regions can affect the efficiency of transcription and potentially modify pri-miRNA or pre-miRNA processing. Since miRNA-based mechanisms are shown to be involved in the pathogenesis of prostate cancer (PCa), the aim of the present study was to evaluate the effect of rs4938723, rs1076064 and rs4705343 occurring in regulatory regions of miR-34b/c, miR-143/145 and miR-378, respectively, on PCa risk and progressi...
As a dynamic system in which different factors affect human performance via dynamic interactions, mental workload needs a dynamic measure to monito r its factors and evidence in a complicated system, an approach that is lacking in the literature. The present study introduces a system dynamics-based model for designing feedback mechanisms related to the mental workload through literature review and content analysis of the previous studies. A human-based archetype o...
Cancer therapies using defects in homologous recombination (HR) DNA repair pathway of tumor cells are not yet approved to be applicable in patients with malignancies other than BRCA1/2-mutated tumors. This study was designed to determine the efficacy of combination therapy of a histone deacetyl ase inhibitor, valproic acid (VPA) and a novel PARP inhibitor AZD2461 in both PC-3 (PTEN-mutated) and DU145 (PTEN-unmutated) prostate cancer cell lines. The Tryp...
Chikungunya virus (CHIKV), a re-emerging infectious arbovirus, causes Chikungunya fever that is characterized by fever, skin rash, joint pain, arthralgia and occasionally death. Despite it has been described for 66 years already, neither potential vaccine nor a specific drug is available yet. During CHIKV infection, interferon type I signaling pathway is stimulated and releases hundreds of interferon stimulated genes (ISGs). Our previous study reported that IFI16, a member of ISGs, ...
Carbon dots (CDs) have outstanding optical properties, biocompatibility, and photostability, making them attractive for imaging applications. A facile and green one-step hydrothermal synthesis method is proposed, which can be safely used in a wide range of applications such as chemical sensing, bioimaging, and optoelectronics. In this study, we report green synthesis of carbon dots from bitter orange juice (Citrus Aurantium) by hydrothermal treatment for the first time. We studied effects o...
Antimicrobial resistance has become a prime global concern. An ability of the microbes to produce enzymes to destroy antimicrobial drugs is one of the well-known mechanisms underlying the resistance. 8-Hydroxyquinoline (8HQ) and derivatives were reported to exert diverse biological effects such as antimicrobial, antioxidant and an- tineurodegenerative activities. Herein, 8HQ (1), nitroxoline (NQ, 2) and 7-Br-8HQ (3) were investigated for antimicrobial activity against Enterobacteriaceae inc...
TOX3 and FOXA1 proteins are believed to be involved in the susceptibility of breast cancer. rs4782447 and rs4784227, as single nucleotide polymorphisms (SNPs), located at the 16q may affect the FOXA1 DNA binding sequence change and therefore may enhance the FOXA1-binding affinity to the promoter of TOX3 gene. This study aimed to investigate the association of these SNPs/haplotypes with breast cancer susceptibility in Iranian population. We conducted a case-control study of 1072 blood samples ...
Long non-coding RNA prostate cancer as sociated transcript-1 ncRNA (lncRNA-PCAT-1) plays an important role in the progression of prostate cancer. The present investigation was aimed to evaluate the potential roles of the lncRNA-PCAT-1 gene expression changes in esophageal squamous cell carcinoma (ESCC) between Iranian population. In the case-control investigation, we have anal yzed a total of 150 fresh tissue samples, compromising of 75 cancerous tissues and 75 adjacent normal tissu...
Curcuminoids are dietary complexes extracted from the seeds of Curcuma longa L. that contain curcumin, bisdemethoxycurcumin and desmethoxycurcumin. Curcuminoids are popular for their pleiotropic therapeutic functions, such as their anti-inflammatory and anti-oxidant effects. Nonetheless, their clinical use is associated with poor systemic bioavailability and insolubility. The nano-formulation of curcuminoids eliminates these shortcomings. In the present study, we explored immuno...
This paper presents a simple and efficient computer-aided diagnosis method to classify Chronic Myeloid Leukemia (CML) cells based on microscopic image processing. In the proposed method, a novel combination of both typical and new features is introduced for cl assification of CML cells. Next, an eff ective decision tree classifier is pro- posed to classify CML cells into eight groups. The proposed method was evaluated on 1730 CML cell images containing 714 cells ...
It has been internationally recognized that malnutrition is an independent risk factor for patients' clinical outcome. A new mandatory fixed price payment system based on diagnosis-related groups (G-DRG) went into effect in 2004. The aim of our study was to demonstrate the importance of carefully coding the secondary diagnosis of "malnutrition" in the G-DRG system and to highlight how the economic relevance of malnutrition in the G-DRG system ha...
Deoxynivalenol (DON) is one of the most common fungal toxins that contaminate food grains and cereal-derived products. However, it is unknown whether DON stimulates IL-1 β expression through the activation of the nuclear factor- κ B (NF- κ B) pathway and the ACS/NLRP3 inflammasome. In this study, we found that high concentrations of DON (above 800 nM) decreased relative cell viability; ho wever, no significant population of apoptotic sub-G 1 cells was observed. DON also ...
- J. G. Hengstler
Leibniz Research Centre for Working Environment and Human Factors
- B. C. Behera, Pune, India
- T. Chen, Stanford, CA/USA
- E. Corsini, Milan, Italy
- P. Diel, Cologne, Germany
- C. Esser, Duesseldorf, Germany
- P. B. Farmer, Leicester/UK
- S. Hammad, South Valley/Egypt
- P. Jennings, Innsbruck, Austria
- M. Lotti, Bonn, Germany / Padova, Italy
- P. Micke, Uppsala, Sweden
- A. N. Misra, Ranchi, Jharkhand State, India
- B. Ponugoti, Pennsylvania, PA/USA
- C. Pope, Stillwater, OK/USA
- K. Renganathan, Johnstown, PA/USA
- S. D. Ray, Fort Wayne, IN/USA
- M. Schwarz, Tuebingen, Germany
- J. Timmer, Freiburg, Germany
- H. van Steeg, Bilthoven, The Netherlands
- A. Winterpacht, Erlangen, Germany
- Y. Zhou, New Haven, CT/USA
Address & Contact:Susanne Lindemann
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Leibniz Research Centre for Working Environment and Human Factors
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