Authors: Kim, Jae Kwang
Park, Sang Un
Title: Recent insights into the biological functions of apigenin
Language (ISO): en
Abstract: Apigenin (4′,5,7-trihydroxyflavone) belongs to the group of flavonoids positioned on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one) and is most extensively allocated in herbs, vegetables, and fruits. Biosynthetically, apigenin is obtained from the phenylpropanoid pathway and also from the flavone synthesis pathway. The pathway of phenylpropanoid begins from the aromatic amino acids L-phenylalanine or L-tyrosine, both products of the shikimate pathway. In several recent studies, it has been shown that apigenin has a number of valuable bioactive functions, including antibacterial, antiviral, antiproliferative, anti-inflammatory, antioxidant, antiangiogenic, and anticancer activities. From the results of several in vivo and in vitro studies and clinical trials, apigenin has been shown to be an effective curative treatment for rheumatoid arthritis, autoimmune disorders, Parkinson’s disease, Alzheimer’s disease, and several types of cancers. Here, we summarize the key findings of the biological and pharmacological actions of apigenin.
Subject Headings: Apigenin
Biological functions
URI: http://hdl.handle.net/2003/39956
http://dx.doi.org/10.17877/DE290R-21846
Publishers Link: https://www.excli.de/index.php/excli/article/view/2579
Issue Date: 2020-07-06
Rights link: https://creativecommons.org/licenses/by/4.0/
Provenance: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Citation: Kim, J. K., & Park, S. U. (2020). Recent insights into the biological functions of apigenin. EXCLI Journal, 19, 984-991. https://doi.org/10.17179/excli2020-2579
Appears in Collections:Letters to the Editor 2020

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