Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Abdel Salam, Omar M. E. | - |
dc.contributor.author | Shaffie, Nermeen M. | - |
dc.contributor.author | Sleem, Amany A. | - |
dc.date.accessioned | 2009-03-11T10:24:25Z | - |
dc.date.available | 2009-03-11T10:24:25Z | - |
dc.date.issued | 2009-03-11T10:24:25Z | - |
dc.identifier.uri | http://hdl.handle.net/2003/26039 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-15693 | - |
dc.description.abstract | The aim of this study was to investigate the effect of citric acid or the sweetening agent aspartame on the CCl4-induced hepatic injury in rats. Citric acid (10 mg/kg, 100 mg/kg or 1000 mg/kg), aspartame (0.625 or 1.25 mg/kg) or silymarin (25 mg/kg) was given once daily orally simultaneously with CCl4 and for one week thereafter. The administration of citric acid at 100 mg/kg or 1000 mg/kg to CCl4-treated rats reduced elevated plasma ALT by 44.1-63.3 %, AST by 47.8-70.6 %, ALP by 41.7-67.2 %, respectively compared to controls. Aspartame at 0.625 or 1.25 mg/kg reduced plasma ALT by 39.8-52.0 %, AST by 43.2-52.4 % and ALP by 50.0-68.5 %, respectively. Meanwhile, silymarin at 25 mg/kg reduced ALT, AST and ALP levels by 52.7, 62.2 and 64.7 %, respectively. On histology, citric acid at 1000 mg/kg resulted in near normalization of liver tissue. Vacuolar degeneration and necrosis were markedly reduced by 1.25 mg/kg aspartame. These results indicate that treatment with citric acid or the sweetening agent aspartame protects against hepatocellular necrosis induced by CCl4. | en |
dc.language.iso | en | - |
dc.relation.ispartofseries | EXCLI Journal ; Vol. 8, 2009 | en |
dc.subject | acute hepatic injury | en |
dc.subject | aspartame | en |
dc.subject | carbon tetrachloride | en |
dc.subject | citric acid | en |
dc.subject | rat | en |
dc.subject | silymarin | en |
dc.subject.ddc | 610 | - |
dc.title | Hepatoprotective effects of citric acid and aspartame on carbon tetrachloride-induced hepatic damage in rats | en |
dc.type | Text | - |
dc.type.publicationtype | article | en |
dcterms.accessRights | open access | - |
eldorado.dnb.zdberstkatid | 2132560-1 | - |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Abdel_Salam_hepatoprotective_proof.pdf | DNB | 352.59 kB | Adobe PDF | View/Open |
This item is protected by original copyright |
This item is protected by original copyright rightsstatements.org