Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Prachayasittikul, Supaluk | - |
dc.contributor.author | Prachayasittikul, Virapong | - |
dc.contributor.author | Ruchirawat, Somsak | - |
dc.contributor.author | Treeratanapiboon, Lertyot | - |
dc.date.accessioned | 2009-07-08T07:20:08Z | - |
dc.date.available | 2009-07-08T07:20:08Z | - |
dc.date.issued | 2009-07-08T07:20:08Z | - |
dc.identifier.uri | http://hdl.handle.net/2003/26216 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-641 | - |
dc.description.abstract | To discover new bioactive lead compounds for medicinal purposes, herein, 2(1-adamantylthio)pyridine and derivatives (1-10) were prepared and tested for antibacterial (agar dilution method against 27 strains of microorganisms), antimalarial (against Plasmodium falciparum) and anticancer (MOLT-3, HepG2, HuCCA-1 and A549) activities. Results showed that all the tested derivatives selectively exerted antigrowth activity against Streptococci at 15-30 µg/mL. 3-Substituted (R) thiopyridines; 3 (R = NAc2), 5 (R = OH) and 6 (R = Br) exhibited antibacterials, antimalarials and anticancers. Significantly, 6-(1-adamantylthio) nicotinonitrile (10) is a promising antibacterial which selectively displays antigrowth activity against Vibrio cholerae, Vibrio parahaemolyticus, Edwardsiella tarda and beta-hemolytic Streptococcus group A with minimum inhibitory concentration of 30 µg/mL. The findings reveal that these 1-adamantylthiopyridines represent a novel class of antibacterial, antimalarial and anticancer agents with potential medicinal values. | en |
dc.language.iso | en | - |
dc.relation.ispartofseries | EXCLI Journal ; Vol. 8, 2009 | en |
dc.subject | 1-adamantylthiopyridines | en |
dc.subject | antibacterial | en |
dc.subject | anticancer activities | en |
dc.subject | antimalarial | en |
dc.subject.ddc | 610 | - |
dc.title | Novel activities of 1-adamantylthiopyridines as antibacterials, antimalarials and anticancers | en |
dc.type | Text | - |
dc.type.publicationtype | article | - |
dcterms.accessRights | open access | - |
eldorado.dnb.zdberstkatid | 2132560-1 | - |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Prachayasittikul_novel_activities_proof.pdf | DNB | 196.13 kB | Adobe PDF | View/Open |
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