Authors: Pingaew, Ratchanok
Prachayasittikul, Supaluk
Prachayasittikul, Virapong
Ruchirawat, Somsak
Worachartcheewan, Apilak
Title: A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity
Language (ISO): en
Abstract: Bioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tetrahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported. Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV. The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively.
Subject Headings: 4-phenylpyridine l-oxide
antimicrobial activity
sulfonium ion
Issue Date: 2010-11-17
Appears in Collections:Original Articles

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