|Title:||A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity|
|Abstract:||Bioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tetrahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported. Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV. The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively.|
|Subject Headings:||4-phenylpyridine l-oxide|
|Appears in Collections:||Original Articles|
Files in This Item:
|Prachayasittikul_270910_proof.pdf||DNB||201.81 kB||Adobe PDF||View/Open|
This item is protected by original copyright
All resources in the repository are protected by copyright.