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dc.contributor.authorLi, Qing-Chan-
dc.contributor.authorSu, Jian-Yu-
dc.contributor.authorZhu, Liang-
dc.date.accessioned2011-08-23T10:19:09Z-
dc.date.available2011-08-23T10:19:09Z-
dc.date.issued2011-08-23-
dc.identifier.urihttp://hdl.handle.net/2003/29028-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-8858-
dc.description.abstractThe anti-inflammatory effect of selagin-7-O-(6″-O-Acetyl-)-β-D-glucoside, isolated from the medicinal herb Cancrinia discoidea (Ledeb.) Poljak, was evaluated for its anti-inflammatory activity in the carrageenin- and serotonin-induced rat paw oedema models of acute inflammation and the cotton pellet-induced granuloma rat model of chronic inflammation. Flavone glycoside at doses of 5, 10, or 20 mg/kg, the clinical anti-inflammatory indo-methacin at 10 mg/kg, or vehicle were administered orally before injection of the pro-inflammatory compound. The test compound showed significant anti-inflammatory activity against paw edema induced by carrageenin or serotonin, most notably at the highest test dose of 20 mg/kg. In the cotton pellet-induced granuloma model, the compound showed dose-dependent anti-inflammatory activity, with the highest effect at 20 mg/kg. In all three assays, the flavone glucoside compound was more active at 20 mg/kg than indomethacin at 10 mg/kg.en
dc.language.isoen-
dc.relation.ispartofseriesEXCLI Journal ; Vol. 10, 2011en
dc.subjectanti-inflammatory activityde
dc.subjectCancrinia discoidea (Ledeb.) Poljaken
dc.subjectselagin-7-O-(6″-O-Acetyl-)-β-D-glucosideen
dc.subject.ddc610-
dc.titleEvaluation of the in vivo anti-inflammatory activity of a flavone glycoside from Cancrinia discoidea (Ledeb.) Poljaken
dc.typeText-
dc.type.publicationtypearticle-
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
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