Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Doungsoongnuen, Sutanun | - |
dc.contributor.author | Pingaew, Ratchanok | - |
dc.contributor.author | Prachayasittikul, Supaluk | - |
dc.contributor.author | Prachayasittikul, Virapong | - |
dc.contributor.author | Ruchirawat, Somsak | - |
dc.contributor.author | Suksrichavalit, Thummaruk | - |
dc.contributor.author | Worachartcheewan, Apilak | - |
dc.date.accessioned | 2011-12-02T09:45:01Z | - |
dc.date.available | 2011-12-02T09:45:01Z | - |
dc.date.issued | 2011-12-02 | - |
dc.identifier.uri | http://hdl.handle.net/2003/29203 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-3249 | - |
dc.description.abstract | In the previous studies, the cytotoxicities of anthranilate sulfonamides were investigated. Herein, the bioactivities of 4-substituted (X = NO2, OCH3, CH3, Cl) benzenesulfonamides of anthranilic acid (5-8) are reported. The results revealed that all sulfonamides selectively exerted antifungal activity (25-50 % inhibition) against C. albicans at 4 μg/mL. Furthermore, compounds 6 and 8 show antioxidative (SOD) activity. These sulfonamides, except for 6, selectively display cytotoxic effects toward MOLT-3 cells. It is interesting to note that sulfonamides with electron withdrawing substituent (5, X = NO2) exhibited the highest cytotoxicity. This study provided preliminary structure-activity relationship of the anthranilic sulfonamides that is useful for further in-depth investigation. | en |
dc.language.iso | en | - |
dc.relation.ispartofseries | EXCLI Journal ; Vol. 10, 2011 | en |
dc.subject | anthranilic acid | en |
dc.subject | antimicrobials | en |
dc.subject | antioxidants | en |
dc.subject | cytotoxicity | en |
dc.subject | sulfonamides | en |
dc.subject.ddc | 610 | - |
dc.title | Investigation on biological activities of anthranilic acid sulfonamide analogs | en |
dc.type | Text | - |
dc.type.publicationtype | article | - |
dcterms.accessRights | open access | - |
eldorado.dnb.zdberstkatid | 2132560-1 | - |
Appears in Collections: | Original Articles |
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Prachayasittikul_071011_proof.pdf | DNB | 154.26 kB | Adobe PDF | View/Open |
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