Authors: Saadat, Iraj
Saadat, Mostafa
Title: Prevalence of G6721T polymorphism of XRCC7 in an Iranian population
Language (ISO): en
Abstract: Genetic polymorphism G6721T (rs.7003908) in gene encoding DNA-dependent protein kinase (DNA-PKcs, encoded by the XRCC7 gene) has been defined. In order to get more insight into the genetic structure of Iranian population the present study was carried out on Iranian Persian population living in Shiraz (Fars province, southwest Iran). The total study subjects consisted of 935 (195 males, 740 females) unrelated healthy individuals. Genotypes of XRCC7 G6721T were detected by PCR-RFLP based method. There was no significant difference between males and females for the XRCC7 polymorphism (χ2=1.275, df=2, P=0.529). Prevalence of the G allele was 0.473 (95 % CI: 0.441-0.505) in our sample. The study population was at Hardy-Weinberg equilibrium for the XRCC7 polymorphism (χ2=0.980, df=1, P=0.323). The allelic frequency of the G allele showed high frequency in Iranian population compared to other populations.
Subject Headings: Iran
population genetics
Issue Date: 2012-09-19
Appears in Collections:Original Articles

Files in This Item:
File Description SizeFormat 
Saadat_15032012_proof.pdfDNB51.93 kBAdobe PDFView/Open

This item is protected by original copyright

All resources in the repository are protected by copyright.