Authors: Eidi, Akram
Mortazavi, Pejman
Rohani, Ali Haeri
Safi, Shahabaldin
Tehrani, Masoud Ebrahim
Title: Hepatoprotective effects of pantothenic acid on carbon tetrachloride-induced toxicity in rats
Language (ISO): en
Abstract: The present study was undertaken to investigate the hepatoprotective effect of pantothenic acid on CCl4-induced liver damage. Male Wistar rats were orally treated with pantothenic acid (0.005, 0.01, 0.025, 0.05 and 0.1 g/kg) daily, with administration of CCl4 (1 mL/kg, 50 % CCl4 in olive oil) twice a week for 28 days. The effect of pantothenic acid on serum markers (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyltransferase)was measured in CCl4-induced hepatotoxicity in rat. Further, the effects on enzymatic antioxidant (superoxide dismutase) were estimated in the liver samples. CCl4 challenge not only elevated the serum marker enzyme activities but also suppressed hepatic antioxidative defense system including superoxide dismutase. The biochemical observations were supplemented with histopathological examination of rat liver sections. Histopathological examination of livers showed that pantothenic acid reduced fatty degeneration, cytoplasmic vacuolization and necrosis in CCl4-treated rats. Therefore, pantothenic acid may be an effective hepatoprotective agent and viable candidate for treating hepatic disorders and other oxidative stress-related diseases.
Subject Headings: antioxidant
carbon tetrachloride
hepatoprotective effects
pantothenic acid
Issue Date: 2013-05-13
Appears in Collections:Original Articles

Files in This Item:
File Description SizeFormat 
Eidi_17112012_proof.pdfDNB423.18 kBAdobe PDFView/Open

This item is protected by original copyright

If no CC-License is given, pleas contact the the creator, if you want to use thre resource other than only read it.