Full metadata record
DC FieldValueLanguage
dc.contributor.authorChaitra, K. L.-
dc.contributor.authorUlaganathan, Kayalvili-
dc.contributor.authorJames, Anita-
dc.contributor.authorAnanthapur, Venkateshwari-
dc.contributor.authorNallari, Pratibha-
dc.date.accessioned2014-03-05T16:56:40Z-
dc.date.available2014-03-05T16:56:40Z-
dc.date.issued2013-11-26-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/32920-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-7137-
dc.description.abstractmiRNAs have been found to play a major role in cardiomyopathy, a heart muscle disorder characterized by cardiac dysfunction. Several miRNAs including those involved in heart development are found to be dysregulated in cardiomyopathy. These miRNAs act either directly or indirectly by controlling the genes involved in normal development and functioning of the heart. Indirectly it also targets modifier genes and genes involved in signaling pathways. In this review, miRNAs involved in heart development, including dysregulation of miRNA which regulate various genes, modifiers and notch signaling pathway genes leading to cardiomyopathy are discussed. A study of these miRNAs would give an insight into the mechanisms involved in the processes of heart development and disease. Apart from this, information gathered from these studies would also generate suitable therapeutic targets in the form of antagomirs which are chemically engineered oligonucleotides used for silencing miRNAs.en
dc.language.isoende
dc.relation.ispartofseriesEXCLI Journal ; Vol. 12, 2013en
dc.subjectmiRNAen
dc.subjectcardiomyopathyen
dc.subjectmodifiersen
dc.subjectsignaling pathwaysen
dc.subject.ddc610-
dc.titlemiRNA regulation during cardiac development and remodeling in cardiomyopathyen
dc.typeTextde
dc.type.publicationtypearticlede
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
Appears in Collections:Review Articles

Files in This Item:
File Description SizeFormat 
Nallari_26112013_proof.pdfDNB325.64 kBAdobe PDFView/Open


This item is protected by original copyright



This item is protected by original copyright rightsstatements.org