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dc.contributor.authorRozita, Mohd-
dc.contributor.authorNoorul Afidza, Mohamad-
dc.contributor.authorRuslinda, Mustafar-
dc.contributor.authorCader, Rizna-
dc.contributor.authorHalim, A. Gafor-
dc.contributor.authorKong, Chiew Tong Norella-
dc.contributor.authorNor Azm, Kamaruddin-
dc.contributor.authorShah, Shamsul Azhar-
dc.date.accessioned2014-03-10T10:42:11Z-
dc.date.available2014-03-10T10:42:11Z-
dc.date.issued2013-06-11-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/32941-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-7481-
dc.description.abstractIntroduction: Hypovitaminosis D is reported to be associated with several medical complications. Recent studies have reported a high worldwide prevalence of Vitamin D deficiency in the general population (up to 80 %). This is even higher in patients with chronic kidney disease (CKD) and increases with advancing stages of CKD. Objectives: To determine the difference in serum Vitamin D [25-hydroxyvitamin D, 25(OH) D] levels between CKD patients and normal healthy population. Materials and Methods: A prospective crosssectional study involving 50 normal volunteers (control) and 50 patients with CKD stages 2-4. Their demographic profiles were recorded and blood samples taken for serum 25(OH) D, intact parathyroid hormone (iPTH) and other routine blood tests. Results: All subjects regardless of renal status had hypovitaminosis D (< 30ng/mL). The mean serum 25(OH) D were comparable in the control and CKD groups (15.3 ± 4.2 ng/mL vs 16.1 ± 6.2 ng/mL, p = NS). However, within the Vitamin D deficient group, the CKD group had lower levels of serum 25(OH) D [12.6( 3.7) ng/mL vs 11.2(6.5) ng/mL, p = 0.039]. Female gender [OR 22.553; CI 95 % (2.16-235.48); p = 0.009] and diabetic status [OR 6.456; CI 95 % (1.144-36.433); p = 0.035] were independent predictors for 25(OH) D deficiency. Conclusions: Vitamin D insufficiency and vitamin D deficiency are indeed prevalent and under-recognized. Although the vitamin D levels among the study subjects and their control are equally low, the CKD group had severe degree of vitamin D deficiency. Diabetic status and female gender were independent predictors of low serum 25(OH)D.en
dc.language.isoen-
dc.relation.ispartofseriesEXCLI Journal ; Vol. 12, 2013en
dc.subject25-hydroxyvitamin Den
dc.subjectvitamin D insufficiency and deficiencyen
dc.subjectnormal populationen
dc.subjectCKD patientsen
dc.subject.ddc610-
dc.titleSerum vitamin D levels in patients with chronic kidney diseaseen
dc.typeText-
dc.type.publicationtypearticle-
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
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