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dc.contributor.authorKim, Min-Jin-
dc.contributor.authorYang, Kyong-Wol-
dc.contributor.authorKim, Sang Suk-
dc.contributor.authorPark, Suk Man-
dc.contributor.authorPark, Kyung Jin-
dc.contributor.authorKim, Kwang Sik-
dc.contributor.authorChoi, Young Hun-
dc.contributor.authorCho, Kwang Keun-
dc.contributor.authorLee, Nam Ho-
dc.contributor.authorHyun, Chang-Gu-
dc.date.accessioned2014-03-12T13:52:03Z-
dc.date.available2014-03-12T13:52:03Z-
dc.date.issued2013-11-07-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/32970-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-7370-
dc.description.abstractA number of essential oils derived from plants are claimed to have several medicinal functions, including anti-cancer and anti-inflammation effects. However, the chemical composition and biological activities of flower-derived components have not been sufficiently characterized. Therefore, we investigated the composition of essential oils from Hallabong flower [(Citrus unshiu Marcov × Citrus sinensis Osbeck) × Citrus reticulata Blanco] and their anti-inflammatory effects. Hydro-dist illed essential oils (HEOs) were analyzed using gas chromatography–mass spectrometry (GC–MS). In total, 21 components were identified, representing more than 98 % of the oils, with sabinene (34.75 %), linalool (14.77 %), β-ocimene (11.07 %), 4-terpineol (9.63 %), L-limonene (5.88 %), and γ-terpinene (4.67 %) as the main components. In the present study, we also investigated the anti-inflammatory effects of HEOs on lipopolysaccharide (LPS)-stimulated RAW 26 4.7 macrophage cells. HEOs were found to inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production and to suppress the LPS- induced expression of cyclooxygenase-2 (COX-2) protein. In addition, HEOs downregulated the production of the inflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1 β(IC50 values are 0.05 %, 0.02 %, and 0.01 %, respectively). On the basis of these results, we suggest that HEOs can be consid ered potential anti-inflammatory candidates for therapeutic use in humans.en
dc.language.isoen-
dc.relation.ispartofseriesEXCLI Journal ; Vol. 12, 2013en
dc.subjectchemical compositionen
dc.subjectcitrus floweren
dc.subjectessential oilen
dc.subjectinflammationen
dc.subjectHallabongen
dc.subject.ddc610-
dc.titleChemical composition and anti-inflammatory effects of essential oil from Hallabong floweren
dc.typeText-
dc.type.publicationtypearticle-
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
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