Authors: | Bahari, Zahra Manaheji, Homa Hosseinmardi, Narges Meftahi, Gholam Hossein Sadeghi, Mehdi Danialy, Samira Noorbakhsh, Seyed Mohammad |
Title: | Induction of spinal long-term synaptic potentiation is sensitive to inhibition of neuronal NOS in L5 spinal nerve-transected rats |
Language (ISO): | en |
Abstract: | The role of neuronal nitric oxide synthase (nNOS) in the central mechanism of neuropathic pain and long-term potentiation (LTP) of peripheral afferents remains obscure. The current study investigated the effect of intrathecal application of 7-nitroindazole (7-NI), a selective nNOS inhibitor (8.15 μg/5μl), on mechanical allodynia on day 14 after L5 spinal nerve transection. Furthermore, using in vivo single unit extracellular recording, we examined the effect of 7-NI on the induction of LTP of Aδ- and C-fiber-evoked responses. We have demonstrated that 7-NI attenuates nerve-injury-evoked mechanical allodynia. Additionally, our electrophysiological study has shown that the spinal administration of 7-NI significantly inhibits the induction of the LTP of Aδ- and C-fiber-evoked responses on day 14 after neuropathy. These data suggest that activation of nNOS may be crucial for the induction of the spinal LTP of Aδ- and C-fiber-evoked responses following peripheral nerve damage. |
Subject Headings: | neuropathic pain nNOS LTP dorsal horn |
URI: | http://hdl.handle.net/2003/33708 http://dx.doi.org/10.17877/DE290R-6845 |
Issue Date: | 2014-07-14 |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Manaheji_14072014_proof.pdf | DNB | 528.84 kB | Adobe PDF | View/Open |
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