Full metadata record
DC FieldValueLanguage
dc.contributor.authorWang, Jing-
dc.contributor.authorDai, Shu-
dc.contributor.authorGuo, Yan-
dc.contributor.authorXie, Wen-
dc.contributor.authorZhai, Yonggong-
dc.date.accessioned2014-11-27T12:41:07Z-
dc.date.available2014-11-27T12:41:07Z-
dc.date.issued2014-07-07-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/33729-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-6707-
dc.description.abstractHormonal homeostasis is essential for a variety of physiological and pathological processes. Elimination and detoxification of xenobiotics, such as drugs introduced into the human body, could disrupt the balance of hormones due to the induction of drug metabolizing enzymes (DMEs) and transporters. Pregnane X receptor (PXR, NR1I2) functions as a master xenobiotic receptor involved in drug metabolism and drug-drug interactions by its coordinated transcriptional regulation of phase I and phase II DMEs and transporters. Recently, increasing evidences indicate that PXR can also mediate the endocrine disrupt or function and thus impact the integrity of the endocrine system. This review focuses primarily on the recent advances in our understanding of the function of PXR in glucocorticoid, mineralocorticoid, androgen and estrogen homeostasis. The elucidation of PXR-mediated drug-hormone interactions might have important therapeutic implications in dealing with hormone-dependent diseases and safety assessment of drugs.en
dc.language.isoen-
dc.relation.ispartofseriesEXCLI Journal ; Vol. 13, 2014en
dc.subjectPXRen
dc.subjecthormone homeostasisen
dc.subjectxenobiotic receptoren
dc.subjectdrug-hormone interactionsen
dc.subject.ddc610-
dc.titleBiology of PXRen
dc.title.alternativeRole in drug-hormone interactionsen
dc.typeText-
dc.type.publicationtypearticle-
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
Appears in Collections:Review Articles

Files in This Item:
File Description SizeFormat 
Zhai_07072014_proof.pdfDNB325.48 kBAdobe PDFView/Open


This item is protected by original copyright



All resources in the repository are protected by copyright.