Authors: Wang, Xiaojing
Ning, Qin
Title: Immune mediated liver failure
Language (ISO): en
Abstract: Liver failure is a clinical syndrome of various etiologies, manifesting as jaundice, encephalopathy, coagulopathy and circulatory dysfunction, which result in subsequent multiorgan failure. Clinically, liver failure is classified into four categories: acute, subacute, acute-on-chronic and chronic liver failure. Massive hepatocyte death is considered to be the core event in the development of liver failure, which occurs when the extent of hepatocyte death is beyond the liver regenerative capacity. Direct damage and immune-mediated liver injury are two major factors involved in this process. Increasing evidence has suggested the essential role of immune-mediated liver injury in the pathogenesis of liver failure. Here,we review the evolved concepts concerning the mechanisms of immune-mediated liver injury in liver failure from human and animal studies. Both innate and adaptive immunity, especially the interaction of various immune cells and molecules as well as death receptor signaling system are discussed. In addition, we highlight the concept of “immune coagulation”, which has been shown to be related to the disease progression and liver injury exacerbation in HBV related acute-on-chronic liver failure.
Subject Headings: Immune
innate immunity
adaptive immunity
humoral immunity
cytokines
liver failure
URI: http://hdl.handle.net/2003/33745
http://dx.doi.org/10.17877/DE290R-6940
Issue Date: 2014-10-01
Appears in Collections:Review Articles

Files in This Item:
File Description SizeFormat 
Ning_02102014_proof.pdfDNB328.64 kBAdobe PDFView/Open


This item is protected by original copyright



All resources in the repository are protected by copyright.