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dc.contributor.authorTila, Dena-
dc.contributor.authorYazdani - Arazi, Seyede Narjes-
dc.contributor.authorGhanbarzadeh, Saeed-
dc.contributor.authorArami, Sanam-
dc.contributor.authorPourmoazzen, Zhaleh-
dc.date.accessioned2015-04-21T07:07:54Z-
dc.date.available2015-04-21T07:07:54Z-
dc.date.issued2015-01-06-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/34011-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-7465-
dc.description.abstractThe aim of this study was the design and evaluation of a novel plasma stable, pH-sensitive niosomal formulation of Mitoxantrone by a modified ethanol injection method. Cholesterol hemisuccinate was added instead of cholesterol in order to produce pH-sensitivity property and using PEG-Poly (monomethyl itaconate)-CholC6 (PEG-PMMI-CholC6) copolymer introduced simultaneously pH-sensitivity and plasma stability properties in prepared niosomes. The pH-sensitivity and cytotoxicity of Mitoxantrone niosomes were evaluated in vitro in phosphate buffer with different pHs as well as using human ovarian cancer cell line (OVCAR-3), human breast cancer cell line (MCF-7) and human umbilical vein endothelial cells (HUVEC). Results showed that both cholesterol derivatives bearing formulations had pH-sensitive property and were found to release their contents under mild acidic conditions rapidly. In addition, the PEG-PMMI-CholC6-based niosomes could reserve the pH-sensitivity after incubation in plasma. Both Mitoxantrone-loaded pH-sensitive niosomes showed higher cytotoxicity than the conventional niosomes on OVCAR-3 and MCF-7 cell lines. However, both pH-sensitive niosomes exhibited lower cytotoxic effect on HUVEC cell line. Plasma stable, pH-sensitive niosomes could improve the cytotoxic effect and reduce the side effects of anti-tumor drugs.en
dc.language.isoen-
dc.relation.ispartofseriesEXCLI Journal ; Vol. 14, 2015en
dc.subjectpH-sensitive plasma stable niosomeen
dc.subjectcytotoxic effecten
dc.subjectMitoxantroneen
dc.subject.ddc610-
dc.titlePH-sensitive, polymer modified, plasma stable niosomes: promising carriers for anti-cancer drugsen
dc.typeText-
dc.type.publicationtypearticle-
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
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